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个人简介
Bart De Strooper is a Belgian molecular biologist and professor at the Katholieke Universiteit Leuven (Leuven, Belgium). He is head of the VIB Department of Molecular and Developmental Genetics, KU Leuven.
Bart De Strooper obtained an MD at the Katholieke Universiteit Leuven in 1985 and a PhD in 1992. He did a Postdoc at the EMBL in Heidelberg Germany in 1994. He is VIB Group leader since 1999, and Scientific Director, Department of Molecular and Developmental Genetics since 2007.
His research interest are the secretases which are proteases which cleave the amyloid peptide from the amyloid precursor protein (APP). The amyloid peptide is the main constituent of the plaques in the brain in Alzheimer's Disease. Together with Christian Haass he received the Potamkin Prize in 2002.
Research focus
We investigate the basic mechanisms causing Alzheimer’s disease and Parkinson’s disease starting from the genetic forms of these disorders.
For Alzheimer’s disease we focus on the secretases which are proteases that cleave the amyloid peptide from the amyloid precursor protein. The amyloid peptide is the main constituent of the plaques in the brain of patients with Alzheimer’s disease. The secretases are not only important drug targets, but they are also involved in the regulation of important signaling processes most notoriously Notch signaling.
For Parkinson’s disease we investigate the effect of mutations in the genes Pink1, Lrrk2 and Parl-1 on brain function.
We use in all our work transgenic approaches primary cultures of neurons and biochemistry, sophisticated imaging and molecular biology to address our questions. We are also strongly committed to collaboration with industry to generate novel drugs for these devastating disorders.
Publications
Lessons from a failed gamma-Secretase Alzheimer trial
De Strooper B
CELL, 159, 721-6, 2014
PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling
Morais Epifânio V, Haddad D, Craessaerts K, De Bock P, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B
SCIENCE, 344, 203-7, 2014
A Self-Organizing miR-132/Ctbp2 Circuit Regulates Bimodal Notch Signals and Glial Progenitor Fate Choice during Spinal Cord Maturation
Salta E, Lau Poui Cheung P, Sala Frigerio C, Coolen M, Bally-Cuif L, De Strooper B
DEVELOPMENTAL CELL, 30, 423-36, 2014
beta-arrestin 2 regulates Abeta generation and gamma-secretase activity in Alzheimer's disease
Thathiah A, Horré K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, de Kloe G, Munck S, De Strooper B
NATURE MEDICINE, 19, 43-9, 2013
LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
Matta S, Van Kolen K, Da Cunha R, Van Den Bogaart G, Mandemakers W, Miskiewicz K, De Bock P, Morais Epifânio V, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars D, De Strooper B, Verstreken P
NEURON, 75, 1008-21, 2012
研究兴趣
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Rajeshwar Narlawar,Lutgarde Serneels, Celia Gaffric,Harrie J. M. Gijsen,Bart De Strooper, Francois Bischoff
JOURNAL OF BIOLOGICAL CHEMISTRYno. 7 (2023)
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M. Koper, S. Moonen, A. Ronisz, S. Ospitalieri, S. Rabe, M. Staufenbiel,B. De Strooper, S. Balusu, D. R. Thal
BRAIN PATHOLOGY (2023)
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Joan Cruz-Sesé,María Alfonso-Triguero, Jon Olano-Bringas, Leire Ruiz, Nuria Galbis,Pranav Preman,An Snellinx,Julia Tcw,Elena Alberdi, Alison Goate,Bart De Strooper,Amaia Mendiguren Arranz
IBRO Neuroscience Reports (2023): S389-S389
Laura Rué,Tom Jaspers, Isabelle M S Degors,Sam Noppen,Dominique Schols,Bart De Strooper,Maarten Dewilde
Pharmaceuticsno. 6 (2023): 1748-1748
Rafaela Policarpo,Leen Wolfs, Saul Martinez-Montero, Lina Vandermeulen,Ines Royaux,Gert Van Peer,Pieter Mestdagh,Annerieke Sierksma,Bart De Strooper, Constantin d'Ydewalle
biorxiv(2023)
BRAINno. 2 (2023): 690-699
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