基本信息
浏览量:23
职业迁徙
个人简介
Research interests
Most human cancers arise in epithelial tissues, such as the skin or intestinal tract. A population of basal stem cells normally proliferates to maintain epithelial homeostasis and to regenerate tissues after damage. The same stem cells are also the origin of tumour formation. We seek to understand how epithelial stem cells normally function and how their activity becomes misregulated in cancers.
My laboratory uses Drosophila, mouse and human organoids in culture as model systems to explore how stem cells construct epithelial tissues during development and how epithelial tumours can arise.
We focus on the questions of how cell polarity organises the behaviour of cells within an epithelium, and how signalling pathways control cell proliferation within an epithelia. A major interest has been the Hippo-YAP/TAZ signalling pathway, which responds to apical and basal polarity cues, cell-matrix interactions, and mechanical forces to regulate cell proliferation and cellular morphology during development.
Our experiments combine three main approaches to identify molecular mechanisms responsible for organising cell polarity and cell behaviour during tissue growth and morphogenesis in epithelia:
Genetic analysis of gene functions in vivo;
Live-imaging of epithelial tissue development; and
Computational modelling of cell polarity and cell behaviour.
Analysis of human cancer patient samples
Most human cancers arise in epithelial tissues, such as the skin or intestinal tract. A population of basal stem cells normally proliferates to maintain epithelial homeostasis and to regenerate tissues after damage. The same stem cells are also the origin of tumour formation. We seek to understand how epithelial stem cells normally function and how their activity becomes misregulated in cancers.
My laboratory uses Drosophila, mouse and human organoids in culture as model systems to explore how stem cells construct epithelial tissues during development and how epithelial tumours can arise.
We focus on the questions of how cell polarity organises the behaviour of cells within an epithelium, and how signalling pathways control cell proliferation within an epithelia. A major interest has been the Hippo-YAP/TAZ signalling pathway, which responds to apical and basal polarity cues, cell-matrix interactions, and mechanical forces to regulate cell proliferation and cellular morphology during development.
Our experiments combine three main approaches to identify molecular mechanisms responsible for organising cell polarity and cell behaviour during tissue growth and morphogenesis in epithelia:
Genetic analysis of gene functions in vivo;
Live-imaging of epithelial tissue development; and
Computational modelling of cell polarity and cell behaviour.
Analysis of human cancer patient samples
研究兴趣
论文共 85 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Teresa T Bonello,Danfeng Cai,Georgina C Fletcher,Kyler Wiengartner, Victoria Pengilly, Kimberly S Lange,Zhe Liu,Jennifer Lippincott-Schwartz,Jennifer M Kavran,Barry J Thompson
Nature Communicationsno. 1 (2021)
引用29浏览0引用
29
0
CURRENT OPINION IN INSECT SCIENCE (2021): 1-10
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn