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We study how cadherins, catenins and associated proteins, and the intercellular junctions they form contribute to the 3-dimensional architecture and physiological functions of tissues and organs. They are important not only for tissue development and regeneration, but also for tissue maintenance and barrier function in numerous organs. We’re also interested in how alterations in their functions contribute to disease processes, including cancer and disrupted barrier functions in inflammation.
A major effort is to understand how cadherin adhesive function at the cell surface is regulated to control morphogenesis, tumor cell invasion, and epithelial and endothelial barrier function. We’ve discovered allosteric regulation of cadherin activity in response to intracellular signals mediated by catenins. We’ve generated a novel class of monoclonal antibodies that activate E-cadherin as probes to understand this process; they are also being used examine the roles of cadherin regulation in a variety of developmental, physiological and pathological processes
A major effort is to understand how cadherin adhesive function at the cell surface is regulated to control morphogenesis, tumor cell invasion, and epithelial and endothelial barrier function. We’ve discovered allosteric regulation of cadherin activity in response to intracellular signals mediated by catenins. We’ve generated a novel class of monoclonal antibodies that activate E-cadherin as probes to understand this process; they are also being used examine the roles of cadherin regulation in a variety of developmental, physiological and pathological processes
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论文共 107 篇作者统计合作学者相似作者
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STRUCTUREno. 2 (2024): 217-227.e3
Molecular biology of the cellno. 5 (2023)
Allison Maker, Madison Bolejack,Leslayann Schecterson,Brad Hammerson, Jan Abendroth,Thomas E Edwards,Bart Staker,Peter J Myler,Barry M Gumbiner
PNAS nexusno. 4 (2022): pgac163-pgac163
Biophysical Journalno. 3 (2022): 526a-526a
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