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个人简介
As a scientist, Dr. Shur made fundamental contributions to our understanding of how cell surface proteins recognize complex carbohydrate ligands during fertilization and development. His lab has used multidisciplinary approaches and diverse model systems, ranging from tissue culture cells to mice and zebrafish to identify novel cell surface receptors and their functions. In 1982, Dr. Shur’s laboratory first made the remarkable and initially controversial discovery that the common housekeeping enzyme, b 1, 4 galactosyltransferase led a dual life, acting also as a receptor on the surface of sperm to aid in recognition of the egg and fertilization. This activity was independent of the enzymatic activity of galactosyltransferase but rather initiated a signaling mechanism that stimulated the sperm acrosome reaction. In 2003, Dr. Shur along with postdoctoral fellow Michael Ensslin, identified SED1, a protein with homology to both EGR and the adhesion protein, discoidin, served as a novel egg receptor on the surface of sperm.
研究兴趣
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Fertility and sterilityno. 6 (2009): 2014-2019
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