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The main projects in my lab focus on how to prevent relapse to cocaine in rats. We use conditioned place preference and drug self-administration models to determine how to diminish drug-associated memories that are thought to cause relapse behavior.
To diminish drug-associated memories, we examine the process of reconsolidation, wherein prior memories can be recalled and subsequently disrupted with appropriate pharmacological agents so that only the recalled memory is diminished. We focus on using specific pharmacological or chemogenetic agents in the prefrontal cortex to disrupt consolidation and reconsolidation of the memories associated with cocaine, thereby suppressing drug-seeking behavior and relapse.
Most of our studies focus on an extracellular matrix structure called the perineuronal net, which is important for acquiring and maintaining drug-associated memories. One function of perineuronal nets is to allow for normal firing of their underlying fast-spiking, parvalbumin interneurons, which regulate the excitatory:inhibitory balance in the brain. We have found that both parvalbumin and perineuronal nets change with the day:night cycle and are most likely regulated by circadian rhythms. Recent studies in our lab use in vivo electrophysiology to decipher how brain oscillations and single cells respond during cocaine-seeking behavior in rats to better understand how brain oscillations might be modified to prevent relapse in humans.
To diminish drug-associated memories, we examine the process of reconsolidation, wherein prior memories can be recalled and subsequently disrupted with appropriate pharmacological agents so that only the recalled memory is diminished. We focus on using specific pharmacological or chemogenetic agents in the prefrontal cortex to disrupt consolidation and reconsolidation of the memories associated with cocaine, thereby suppressing drug-seeking behavior and relapse.
Most of our studies focus on an extracellular matrix structure called the perineuronal net, which is important for acquiring and maintaining drug-associated memories. One function of perineuronal nets is to allow for normal firing of their underlying fast-spiking, parvalbumin interneurons, which regulate the excitatory:inhibitory balance in the brain. We have found that both parvalbumin and perineuronal nets change with the day:night cycle and are most likely regulated by circadian rhythms. Recent studies in our lab use in vivo electrophysiology to decipher how brain oscillations and single cells respond during cocaine-seeking behavior in rats to better understand how brain oscillations might be modified to prevent relapse in humans.
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Jereme C Wingert, Jonathan D Ramos, Sebastian X Reynolds,Angela E Gonzalez, R Mae Rose,Deborah M Hegarty,Sue A Aicher, Lydia G Bailey,Travis E Brown,Atheir I Abbas,Barbara A Sorg
bioRxiv : the preprint server for biology (2024)
Jereme C Wingert, Jonathan N Anguiano,Jonathan D Ramos,Jordan M Blacktop,Angela E Gonzalez,Lynn Churchill,Barbara A Sorg
Addiction biologyno. 11 (2023)
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Antioxidants (Basel, Switzerland)no. 5 (2023): 1124-1124
B. A. Sorg, J. Wingert,A. E. Gonzalez, J. Anguiano,J. H. Harkness,S. A. Aicher, D. M. Hegarty,E. T. Jorgensen, T. E. Brown
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