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Our laboratory studies the pathogenesis of intraventricular hemorrhage (IVH) and evaluates neuro-protective strategies to prevent brain injury after IVH in premature infants. The major projects in our laboratory are focused on determining a) the mechanisms underlying white matter injury in premature infants with IVH and approaches to minimize the damage, b) the effect of IVH on glutamatergic neurogenesis and corticogenesis in the developing brain, and strategies to restore these processes, and c) the effect of prematurity on neurogenesis and corticogenesis.
To answer our research questions, we employ a preterm rabbit model (in vivo studies) and an in vitro organotypic forebrain slice culture model of IVH. Our glycerol model of IVH in preterm rabbits exhibits periventricular white matter injury and post-hemorrhagic hydrocephalus similar to that seen in human preterm survivors with IVH. In addition, we analyze autopsy samples from preterm infants with and without IVH. Commonly used techniques include Immunohistochemistry, confocal microscopy, stereological quantification of neural cells, Western blot analyses, real time qPCR, slice culture, neuronal migration studies, viral gene transfer, flow-cytometry, and magnetic bead isolation of cells.
To answer our research questions, we employ a preterm rabbit model (in vivo studies) and an in vitro organotypic forebrain slice culture model of IVH. Our glycerol model of IVH in preterm rabbits exhibits periventricular white matter injury and post-hemorrhagic hydrocephalus similar to that seen in human preterm survivors with IVH. In addition, we analyze autopsy samples from preterm infants with and without IVH. Commonly used techniques include Immunohistochemistry, confocal microscopy, stereological quantification of neural cells, Western blot analyses, real time qPCR, slice culture, neuronal migration studies, viral gene transfer, flow-cytometry, and magnetic bead isolation of cells.
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Sunil Krishna,Bokun Cheng,Deep R Sharma, Sunita Yadav,Erin S Stempinski,Sahil Mamtani, Elisa Shah, Anjali Deo, Trishna Acherjee, Teena Thomas, Xusheng Zhang,Jinghang Zhang,
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