Roe is the founding director of the Advanced Center for Genomic Technology (ACGT) at the U. of Oklahoma, one of the first large-scale sequencing facilities in the US. At present, the ACGT innovates computational and robotic methods to analyze DNA sequence results and is currently determining the nucleotide sequence of five microbial genomes. In 1999, Roe’s research led to the elucidation and publication of the complete sequence of human chromosome 22. This was the first human chromosome to be sequenced in its entirety.