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Research Interests
Our research interests focus on proteins that are involved in signal transduction pathways of the innate immune system. The human immune system is generally divided into two broad categories, the adaptive immune system and the innate immune system. Adaptive immunity relies on a very large repertoire of clonally distributed antigen receptors displayed on lymphocytes and secreted antibodies that have the ability to recognize almost any foreign molecule. Conversely, innate immunity depends on a limited set of germ-line encoded receptors, which recognize distinct molecular patterns on pathogen surfaces. These receptors are strategically expressed on cells that are likely to encounter antigen early in an infection, including cells of the respiratory tract, epithelial cells of the gut and skin, and professional antigen presenting cells. As a result, the innate immune response generally precedes the adaptive immune response.
Our research interests focus on proteins that are involved in signal transduction pathways of the innate immune system. The human immune system is generally divided into two broad categories, the adaptive immune system and the innate immune system. Adaptive immunity relies on a very large repertoire of clonally distributed antigen receptors displayed on lymphocytes and secreted antibodies that have the ability to recognize almost any foreign molecule. Conversely, innate immunity depends on a limited set of germ-line encoded receptors, which recognize distinct molecular patterns on pathogen surfaces. These receptors are strategically expressed on cells that are likely to encounter antigen early in an infection, including cells of the respiratory tract, epithelial cells of the gut and skin, and professional antigen presenting cells. As a result, the innate immune response generally precedes the adaptive immune response.
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论文共 86 篇作者统计合作学者相似作者
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Biology Methods and Protocols (2024)
TianMeng Xu,Rachel Heon-Roberts, Travis Moore,Patricia Dubot,Xuefang Pan,Tianlin Guo, Christopher W Cairo,Rebecca Holley,Brian Bigger,Thomas M Durcan,Thierry Levade,Jerôme Ausseil,
bioRxiv : the preprint server for biology (2024)
Science Advancesno. 20 (2023): eadf8169-eadf8169
Yue Liang, Garvit Bhatt,Lin Tze Tung,HanChen Wang, Joo Eun Kim, Marwah Mousa,Viktoria Plackoska,Katalin Illes, Anna A. Georges,Philippe Gros,Linda Henneman,Ivo J. Huijbers,
Nahum Sonenberg,Peng Wang,Zixian Li,Sung Hoon Kim, Hao Huang,Jung‐Hyun Choi,Haijin Xu, Chang-Hao Yang, Alison Snape,Sara Bermudez,Marie-Noëlle Boivin, Nicolas Ferry,
Research Square (Research Square) (2023)
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Cell reportsno. 1 (2020): 108230-108230
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