基本信息
浏览量:6
职业迁徙
个人简介
My laboratory is based at the MRC Centre for Molecular Bacteriology & Infection (CMBI) at the South Kensington campus. We study the role of inflammasome signalling networks in host immunity and inflammation. I also have a Satellite Group at the Francis Crick Institute, London.
Inflammasomes are large multimeric signalling scaffolds that activate caspase-1. Inflammasome activation can also require assistance from caspase-4 (also called caspase-11 in the mouse), and caspase-8. Together, these inflammatory caspases launch a robust host defence programme by acting on their targets. My laboratory studies inflammasomes in the context of infection by enteric bacterial pathogens e.g. Salmonella and pathogenic E. coli. We also collaborate with groups within the CMBI to study infections by pathogens such as Mycobacterium and Shigella, and outside Imperial on pathogens such as Toxoplasma gondii.
In addition, inflammasomes can also instigate autoinflammation associated with various non-communicable diseases, including the metabolic syndrome, diabetes and cancer. We are also interested in investigating how natural genetic mutations can predispose individuals to inflammation.
Inflammasomes are large multimeric signalling scaffolds that activate caspase-1. Inflammasome activation can also require assistance from caspase-4 (also called caspase-11 in the mouse), and caspase-8. Together, these inflammatory caspases launch a robust host defence programme by acting on their targets. My laboratory studies inflammasomes in the context of infection by enteric bacterial pathogens e.g. Salmonella and pathogenic E. coli. We also collaborate with groups within the CMBI to study infections by pathogens such as Mycobacterium and Shigella, and outside Imperial on pathogens such as Toxoplasma gondii.
In addition, inflammasomes can also instigate autoinflammation associated with various non-communicable diseases, including the metabolic syndrome, diabetes and cancer. We are also interested in investigating how natural genetic mutations can predispose individuals to inflammation.
研究兴趣
论文共 65 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Rupert Beale, Carmen Figueras-Novoa, Masato Akutsu, Daichi Murata, Ming Jiang,Beatriz Montaner, Christelle Dubois,Avinash R Shenoy
biorxiv(2024)
Vishwas Mishra,Anna Crespo-Puig, Callum McCarthy,Tereza Masonou,Izabela Glegola-Madejska,Alice Dejoux,Gabriella Dow,Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng,Shijie Wang,Daniel J. Bennison,
Nature communicationsno. 1 (2023): 4385-16
引用0浏览0WOSNATURE引用
0
0
Ana Jeemin Choi,Daniel J. Bennison, Esha Kulkarni,Haoyu Sun,Hanqi Li,Jonathan Bradshaw,Hui Wen Yeap,Vishwas Mishra, Anna Crespo-Puig,Frances Davies,Shiranee Sriskandan,Avinash R. Shenoy
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
Ana J. Choi, Daniel J. Bennison, Esha Kulkarni,Haoyu Sun,Hanqi Li,Jonathan Bradshaw,Hui Wen Yeap, Nicholas Lim,Vishwas Mishra, Anna Crespo-Puig,Frances Davies,Shiranee Sriskandan,
biorxiv(2023)
引用0浏览0引用
0
0
Daniel Fisch, Moritz M. Pfleiderer,Eleni Anastasakou,Gillian M. Mackie, Fabian Wendt, Xiangyang Liu,Barbara Clough,Samuel Lara-Reyna,Vesela Encheva,Ambrosius P. Snijders,Hironori Bando,Masahiro Yamamoto,
SCIENCEno. 6666 (2023): 67-+
Vishwas Mishra,Anna Crespo-Puig, Callum McCarthy,Tereza Masonou,Izabela Glegola-Madejska,Alice Dejoux,Gabriella Dow,Matthew J. G. Eldridge, Luciano H. Marinelli, Meihan Meng,Shijie Wang,Daniel J. Bennison,
biorxiv(2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn