基本信息
浏览量:66
职业迁徙
个人简介
Aurelio Teleman at DKFZ investigates how cells use protein networks, called signaling cascades, to adapt to changing environmental conditions. His research focuses on signaling pathways that control cell growth and metabolism. Since a large portion of metabolic energy is needed for cell growth, these two processes need to happen in a coordinated way. From a medical point of view, these signaling pathways are extremely relevant, because errors in these pathways can lead to cancer or metabolic diseases such as obesity and diabetes. Thus, in about 80 percent of all human cancers the activity of the insulin signaling pathway is significantly increased.
Since the above mentioned signaling pathways control basic cellular processes, both the molecular components and the physiological effects are very similar from fruit fly through to man. Therefore, Teleman uses Drosophila as a study object and utilizes the many genetic tools that are available for this organism. Using genetically manipulated flies, Teleman and his team are investigating how development of the animals changes in response to interfering with the relevant signaling pathways. The results are expected to help us gain a better understanding of metabolic diseases.
Since the above mentioned signaling pathways control basic cellular processes, both the molecular components and the physiological effects are very similar from fruit fly through to man. Therefore, Teleman uses Drosophila as a study object and utilizes the many genetic tools that are available for this organism. Using genetically manipulated flies, Teleman and his team are investigating how development of the animals changes in response to interfering with the relevant signaling pathways. The results are expected to help us gain a better understanding of metabolic diseases.
研究兴趣
论文共 126 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Mette Lassen,Keith Pardee, Lisa H. Pedersen,Olga Kubrak,Takashi Koyama, Sasha Necakov, Suya Liu, Arnis Kuksis,Gilles Lajoie,Aled Edwards,Aurelio A. Teleman, Martin R. Larsen,
crossref(2024)
Carlos Camilleri-Robles, Raziel Amador, Marcel Tiebe,Aurelio A Teleman,Florenci Serras, Roderic Guigó,Montserrat Corominas
crossref(2024)
引用0浏览0WOSNATURE引用
0
0
Cellno. 23 (2023): 5114-5134.e27
Jana Samarin,Piotr Fabrowski,Roman Kurilov,Hana Nuskova, Johanna Hummel-Eisenbeiss, Hannelore Pink, Nan Li, Vivienn Weru,Hamed Alborzinia,Umut Yildiz,Laura Grob,Minerva Taubert,
CELLno. 23 (2023): 5114-+
biorxiv(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn