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职业迁徙
个人简介
The main areas of current research are:
1) Interactions between maternal Killer-cell Immunoglobulin-like Receptor (KIR) and fetal HLA-C molecules. Because both KIR and HLA-C genes are highly polymorphic, each pregnancy is likely to be different. Our genetic and functional studies in Europeans and Africans show certain KIR/HLA-C genetic combinations are associated with extremes of the normal birth weight distribution.
2) Culture of human trophoblast cells. Studies on pregnancy disorders are limited because trophoblast stem cell lines have not been obtained. We are working to identify, isolate and culture trophoblast cells from early pregnancy.
3) Maternal Health Research Unit linked to Makerere University, Mulago Hospital, Kampala, Uganda. After the success of our initial project studying Immunogenetics of KIR/HLA-C variants linked to pre-eclampsia in Ugandans, we are now extending the link to investigate puerperal sepsis and obstructed labour. I lead the maternal health theme as part of the Wellcome Trust Centre for Global Health Research.
1) Interactions between maternal Killer-cell Immunoglobulin-like Receptor (KIR) and fetal HLA-C molecules. Because both KIR and HLA-C genes are highly polymorphic, each pregnancy is likely to be different. Our genetic and functional studies in Europeans and Africans show certain KIR/HLA-C genetic combinations are associated with extremes of the normal birth weight distribution.
2) Culture of human trophoblast cells. Studies on pregnancy disorders are limited because trophoblast stem cell lines have not been obtained. We are working to identify, isolate and culture trophoblast cells from early pregnancy.
3) Maternal Health Research Unit linked to Makerere University, Mulago Hospital, Kampala, Uganda. After the success of our initial project studying Immunogenetics of KIR/HLA-C variants linked to pre-eclampsia in Ugandans, we are now extending the link to investigate puerperal sepsis and obstructed labour. I lead the maternal health theme as part of the Wellcome Trust Centre for Global Health Research.
研究兴趣
论文共 193 篇作者统计合作学者相似作者
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Imelda NAMAGEMBE, Babu KARAVADRA, Lawrence KAZIBWE,Joseph RUJUMBA,Noah KIWANUKA,Brandon SMITH,Josaphat BYAMUGISHA,Ashley MOFFETT,Tom BASHFORD,Annettee NAKIMULI,Catherine E AIKEN
AJOG Global Reportspp.100348, (2024)
Qian Li,Andrew Sharkey,Megan Sheridan, Elisa Magistrati,Anna Arutyunyan,Oisin Huhn,Carmen Sancho-Serra, Holly Anderson,Naomi Mcgovern,Laura Esposito,Ridma Fernando,Lucy Gardner,
CELL STEM CELLno. 2 (2024): 181-195.e9
Developmental Cellno. 6 (2024): 693-694
Margherita Turco, Elisa Magistrati, Qian Li,Anna Arutyunyan,Megan Sheridan, Ida Calvi,Andrew Sharkey,Roser Vento-Tormo,Ashley Moffett
Placenta (2023): e3-E3
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Anja Pinborg,Jens Bentzen,G Bozdag, Thomas Ebner,Joyce Harper,Nathalie Le Clef,Ashley Moffett, Sarah Norcross,Polyzos NP, S Rautakallio-Hokkanen,Ioannis A. Sfontouris,Karen Sermon,
Human Reproductionno. Supplement_1 (2023)
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Human reproduction (Oxford, England) (2023)
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Obstetrics, Gynaecology & Reproductive Medicineno. 9 (2023): 268-270
Qian Li,Andrew Sharkey,Megan Sheridan, Elisa Magistrati,Anna Arutyunyan,Oisín Huhn,Carmen Sancho-Serra, Holly E. Anderson,Naomi McGovern,Laura Esposito,Ridma C. Fernando,Lucy Gardner,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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