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个人简介
In Shikanov laboratory we are interested in creating artificial constructs that direct tissue regeneration and restore biological function by combining approaches from engineering, materials, chemistry and life sciences. The clinical problem we want to solve is premature ovarian insufficiency (POI), which is a common outcome of anticancer treatments in young girls and women. POI causes sterility and complications related to absent ovarian endocrine function such as premature osteopenia, muscle wasting, impaired cognitive development, and accelerated cardiovascular disease. We aim to engineer a biomimetic environment that promotes in vitro growth of immature follicles and integrates cellular, molecular and physico-chemical properties with a structural design that allows studying the bi-directional interactions between the follicles and the support cells. Engineered ovarian tissue with controlled physical and biological properties provides supportive environment for ovarian follicle survival and development, graft remodeling and longevity after transplantation. Our lab is also interested in molecular mechanisms involved in early stage development of ovarian follicles, development of novel 3D culture systems and immunoisolating hydrogels for ovarian follicles.
Research Areas: Artificial Organs, Biomaterials, Drug Delivery and Therapeutics, Tissue Engineering and Regenerative Medicine
Research Areas: Artificial Organs, Biomaterials, Drug Delivery and Therapeutics, Tissue Engineering and Regenerative Medicine
研究兴趣
论文共 139 篇作者统计合作学者相似作者
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Brandon W Henry,Cynthia Dela Cruz, Robert W Goulet,Bonnie T Nolan, Conor Locke,Vasantha Padmanabhan,Molly B Moravek,Ariella Shikanov,Megan L Killian
bioRxiv : the preprint server for biology (2024)
Alicia Marco, Marta Gargallo, Jesús Ciriza,Ariella Shikanov, Laura Baquedano, Javier García Pérez-Llantada,Clara Malo
BIOACTIVE MATERIALS (2024): 292-303
Andrea S K Jones, D Ford Hannum,Jordan H Machlin, Ansen Tan,Qianyi Ma,Nicole D Ulrich,Yu-Chi Shen, Maria Ciarelli,Vasantha Padmanabhan,Erica E Marsh,Sue Hammoud,Jun Z Li,
Science advancesno. 14 (2024): eadm7506-eadm7506
Natalia Pascuali,Yong Pu, Anita A Waye,Sarah Pearl,Denny Martin, Allison Sutton,Ariella Shikanov,Almudena Veiga-Lopez
Environmental health perspectivesno. 4 (2024): 47009-47009
bioRxiv : the preprint server for biology (2024)
International Journal of Molecular Sciencesno. 3 (2024): 1510
Monica A Wall,Mayara Garcia de Mattos Barbosa, Natalie Hanby, Michelle M Cai, Margaret Brunette, Despina I Pavlidis, Paula Arrowsmith, Ansen Q Tan,Marilia Cascalho,Ariella Shikanov
International journal of molecular sciencesno. 6 (2024): 3431
Russell Urie, Lauren Hesse, Chengchuan Xiao, Elizabeth Lombard,Elizabeth Hughes,Ariella Shikanov,Lonnie Shea
American Journal of Obstetrics and Gynecologyno. 1 (2024): S610-S611
Gabrielle M Blevins,Colleen L Flanagan, Sridula S Kallakuri, Owen M Meyer,Likitha Nimmagadda, James D Hatch, Sydney A Shea,Vasantha Padmanabhan,Ariella Shikanov
Biology of Reproduction (2024)
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