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My research focuses on the utilization of existing chirality of amino acids, readily available naturally existing ultra pure (100% ee) starting materials, the concept of internal asymmetric induction, i.e. processes where further chirality is introduced from the existing chiral centers in the starting molecule. The utilization of this chiral information necessitates thorough understanding of the intricate structural features and dynamics of the small molecules.
The development of novel synthetic reactions is at the very heart of our educational and research strategy. Solving important synthetic problems to provide useful reactions to e.g. the chemical industry is always a valuable goal. At the same time, I firmly believe that the state of the art of organic synthesis is defined be the complexity of the target structures that can be attacked; not necessarily judged by the number of the chiral centers, but more so by the scientific challenge presented by the structure. It is also beyond doubt that the best training for a synthetic chemist is provided by a total synthesis of complex natural products to prepare the apprentice for any multistep strategy oriented synthesis of any complex structure, be it a natural product, drug molecule or any other ‘high-tech’ functional structure. For these reasons, many of my students have a natural product as their general framework to develop the new chemistry. The complex target structures also force the students to cover the methodology development in a more general way; within such projects, we have recently developed general methods for organocatalytic pericyclic reactions, catalytic air oxidations and organometallic cyclizations. In all our efforts, we take it for granted that current synthesis must conform to the values of sustainability.
The development of novel synthetic reactions is at the very heart of our educational and research strategy. Solving important synthetic problems to provide useful reactions to e.g. the chemical industry is always a valuable goal. At the same time, I firmly believe that the state of the art of organic synthesis is defined be the complexity of the target structures that can be attacked; not necessarily judged by the number of the chiral centers, but more so by the scientific challenge presented by the structure. It is also beyond doubt that the best training for a synthetic chemist is provided by a total synthesis of complex natural products to prepare the apprentice for any multistep strategy oriented synthesis of any complex structure, be it a natural product, drug molecule or any other ‘high-tech’ functional structure. For these reasons, many of my students have a natural product as their general framework to develop the new chemistry. The complex target structures also force the students to cover the methodology development in a more general way; within such projects, we have recently developed general methods for organocatalytic pericyclic reactions, catalytic air oxidations and organometallic cyclizations. In all our efforts, we take it for granted that current synthesis must conform to the values of sustainability.
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