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个人简介
My primary research focus is vascular aging, in particular the cellular, molecular and tissue specific events that induce reductions in muscle blood flow during exercise, impair arterial endothelial function and stiffen large elastic arteries in older rodents/adults. These vascular phenotypes contribute to the age related decline in functional capacity and the development of cardiovascular disease, and can be ameliorated by lifestyle interventions such as habitual exercise and caloric restriction. My secondary focus, is to elucidate the cellular pathways which confer the vaso-protective effects of these lifestyle interventions and try to activate these pathways pharmacologically to see if this will confer some of the same benefits. I have used human, rodent, and cell models to address these questions and utilized a wide range of contemporary translational experimental techniques from microRNA gene expression to ultrasonography to investigate the aforementioned interests.
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AGING CELLno. 2 (2024): e14040-e14040
Md Torikul Islam,Jinjin Cai, Shanena Allen, Denisse G Moreno,Samuel I Bloom,R Colton Bramwell, Jonathan Mitton,Andrew G Horn,Weiquan Zhu,Anthony J Donato,William L Holland,Lisa A Lesniewski
Arteriosclerosis, thrombosis, and vascular biologyno. 5 (2024): 1101-1113
Colin J. Gimblet, Jackson W. Ernst, Kyle D. Bos, Amy K. Stroud,Anthony J. Donato,Diana I. Jalal,Gary L. Pierce
JOURNAL OF APPLIED PHYSIOLOGYno. 2 (2024): 330-336
AGING-USno. 19 (2023): 9931-9947
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PloS oneno. 5 (2023): e0285253-e0285253
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Jisok Lim,John Kim,Venkateswara Gogulamudi, Adelola Adeyemo, Colton Bramwell,Lisa Lesniewski,Anthony Donato
PHYSIOLOGYno. S1 (2023)
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