Anthony R Fehr

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SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

Clayton J Otter, Nicole Bracci,Nicholas A Parenti, Chengjin Ye,Abhishek Asthana, Ebba K Blomqvist, Li Hui Tan,Jessica J Pfannenstiel, Nathaniel Jackson,Anthony R Fehr, Robert H Silverman, James M Burke,

Proceedings of the National Academy of Sciences of the United States of Americano. 15 (2024): e2320194121-e2320194121

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Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target

Sarah Wazir, Tomi A O Parviainen,Jessica J Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff,Sven T Sowa, Albert Galera-Prat,Dana Ferraris, Mirko M Maksimainen,Anthony R Fehr, Juha P Heiskanen,Lari Lehtiö

Journal of medicinal chemistry（2024）

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Mutation of highly conserved residues in loop 2 of the coronavirus macrodomain demonstrates that enhanced ADP-ribose binding is detrimental to infection

Catherine M. Kerr,Jessica J. Pfannenstiel,Yousef M. Alhammad,Anuradha Roy,Joseph J. O’Connor,Roshan Ghimire, Reem Khattabi, Rakshya Shrestha,Peter R. McDonald,Philip Gao,David K. Johnson,Sunil More,

biorxiv（2024）

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PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses

Srivatsan Parthasarathy, Pradtahna Saenjamsai, Hongping Hao, Anna Ferkul, Jessica J Pfannenstiel,Ellen L Suder,Daniel S Bejan,Yating Chen,Nancy Schwarting,Masanori Aikawa,Elke Muhlberger,Robin C Orozco,

bioRxiv : the preprint server for biology (2024)

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PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner

Catherine M. Kerr,Srivatsan Parthasarathy,Nancy Schwarting,Joseph J. O'Connor,Jessica J. Pfannenstiel,Emily Giri,Sunil More,Robin C. Orozco,Anthony R. Fehr

JOURNAL OF VIROLOGYno. 9 (2023)

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An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors

Joseph J. O'Connor,Dana Ferraris,Anthony R. Fehr

Pathogens (Basel, Switzerland)（2023）

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Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target

Sarah Wazir, Tomi A O Parviainen, Jessica J Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff,Sven T Sowa,Albert Galera-Prat,Dana Ferraris,Mirko M Maksimainen,Anthony R Fehr,Juha P Heiskanen,Lari Lehtiö

bioRxiv : the preprint server for biology (2023)

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SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

Yousef M. Alhammad,Srivatsan Parthasarathy,Roshan Ghimire,Joseph J. O’Connor,Catherine M. Kerr,Jessica J. Pfannenstiel,Debarati Chanda, Caden A. Miller, Robert L. Unckless,Sonia Zuniga,Luis Enjuanes,Sunil More,

biorxiv（2023）

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PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

Catherine M Kerr,Srivatsan Parthasarathy,Nancy Schwarting,Joseph J O'Connor,Emily Giri,Sunil More,Robin C Orozco,Anthony R Fehr

bioRxiv : the preprint server for biology (2023)

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Discovery of 2-amide-3-methylester thiophenes inhibiting SARS-CoV-2 ADP-ribosyl hydrolysing macrodomain and coronavirus replication

Sarah Wazir, Tomi A. O. Parviainen,Mirko M. Maksimainen,Men Thi Hoai Duong,Jessica J Pfannenstiel, D. Cluff,Sven T. Sowa,Albert Galera‐Prat,Dana Ferraris,Anthony R. Fehr,Juha P. Heiskanen,L. Lehtiö

bioRxiv (Cold Spring Harbor Laboratory) (2023)

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