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The theme of his research programme is ‘vascular inflammation’, focusing on the cellular and molecular mechanisms involved in vascular rejection. He has shown that coagulation proteases, such as thrombin, play a critical role in inflammatory vascular disease, including rejection and atherosclerosis. These same pathways are also involved in chronic arteriosclerosis and tissue fibrosis. He is co-inventor of a novel therapeutic, called Thrombalexin, that is expected to undergo first in man testing in 2019/20. Clinically, he focuses on patients undergoing antibody-incompatible transplantation and in those with chronic rejection. His translational work has confirmed that B cells play a significant role in processing and presenting donor antigens in these patients, but has revealed a heterogeneous complexity that includes maintenance of tolerance mechanisms in a significant proportion of patients. He is co-PI of the large UK RCT OuTSMART.
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Transplant international : official journal of the European Society for Organ Transplantation (2023): 11616
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Miriam Manook,Lisa Mumford,Alec Nicholas R Barnett, Daniel Osei-Bordom,Bynvant Sandhu, David Veniard,Tim Maggs,Olivia Shaw,Nicos Kessaris,Anthony Dorling,Sapna Shah,Nizam Mamode
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