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One third of all currently used medicines target G-protein-coupled receptors (GPCRs) belonging to Class 1 or Family A, part of the ‘druggable genome’. The aim of our research is to understand the role of GPCRs, together with their transmitters in the human cardiovascular system and how these are altered with disease, in particular the consequences of endothelial cell dysfunction, to identify new targets for novel drugs.
We focus on discovering the role in humans of novel ‘orphan’ GPCRs, originally predicted to exist from the human genome but recently paired with their cognate transmitters. Using this approach, we have characterized GPCRs expressed in the human cardiovascular system and identified a novel cardiovacular role for transmitters including apelin, chemokines and kisspeptins.
One third of all currently used medicines target G-protein-coupled receptors (GPCRs) belonging to Class 1 or Family A, part of the ‘druggable genome’. The aim of our research is to understand the role of GPCRs, together with their transmitters in the human cardiovascular system and how these are altered with disease, in particular the consequences of endothelial cell dysfunction, to identify new targets for novel drugs.
We focus on discovering the role in humans of novel ‘orphan’ GPCRs, originally predicted to exist from the human genome but recently paired with their cognate transmitters. Using this approach, we have characterized GPCRs expressed in the human cardiovascular system and identified a novel cardiovacular role for transmitters including apelin, chemokines and kisspeptins.
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IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
Nucleic acids researchno. D1 (2023): D1438-D1449
NATURE CARDIOVASCULAR RESEARCHno. 11 (2023): 972-990
BRITISH JOURNAL OF PHARMACOLOGY (2023): 1216-1216
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IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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NEPHROLOGY DIALYSIS TRANSPLANTATION (2023): I672-I673
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Anthony P. Davenport, Stephen A. Douglas,Alain Fournier, Adel Giaid,Henry Krum,David G. Lambert,Jérôme Leprince,Margaret R. MacLean,Eliot H. Ohlstein,Walter G. Thomas,Hervé Tostivint,David Vaudry,
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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