基本信息
浏览量:45
职业迁徙
个人简介
Research Activities
Our laboratory is interested in the pathogenesis of bacterial infections and the development of vaccines for their prevention. The primary focus is on a system we discovered that allows certain Gram-negative bacteria to obtain iron for growth in vivo by directly obtaining iron from the host's iron binding proteins, transferrin and lactoferrin. This system involves receptors at the bacterial surface that bind transferrin or lactoferrin as a first step in the iron acquisition process. The two main goals of our research are to determine the detailed mechanisms involved in the iron uptake pathway and to develop effective vaccines and therapeutic agents against pathway components.
The surface receptors are essential for survival of the bacteria in vivo, indicating that they are ideal vaccine targets. Receptor proteins from different bacteria that cause meningitis, lung infections and ear infections in humans and pneumonia in cattle and pigs have been tested for efficacy and licensed to companies interested in developing human and veterinary vaccines. However, vaccine development is currently hampered by antigenic variation of the receptor proteins. Our goal is to develop effective, broad-spectrum, long-lasting vaccines based on the conserved regions of the receptor proteins that are required for function.
研究兴趣
论文共 141 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nicholas K H Ostan, Gregory B Cole, Flora Zhiqi Wang,Sean E Reichheld, Gaelen Moore,Chuxi Pan,Ronghua Yu,Christine Chieh-Lin Lai,Simon Sharpe,Hyun O Lee,Anthony B Schryvers,Trevor F Moraes
PNAS nexusno. 4 (2024): pgae139-pgae139
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
Epshita A Islam,Jamie E Fegan,Takele A Tefera,David M Curran, Regula C Waeckerlin,Dixon Ng,Sang Kyun Ahn, Chun Heng Royce Lai, Quynh Huong Nguyen,Megha Shah, Liyuwork Tesfaw,Kassaye Adamu,
Somshukla Chaudhuri,Iraj Rasooli, Ramin Hatefi Oskouei,Mahdi Pishgahi,Abolfazl Jahangir,Vahid Farshchi Andisi,Anthony B Schryvers
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn