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个人简介
Our laboratory conducts basic research on paramyxoviruses that cause serious and prevalent childhood diseases, and on newly emerging paramyxoviruses that affect humans. We investigate common pediatric respiratory viruses (parainfluenza viruses, respiratory syncytial virus) as well as emerging lethal henipaviruses (Nipah and Hendra viruses). The focus is on the mechanisms of viral entry into host cells, in the intial stages of infection. The laboratory is best known for identifying critical roles of the viral receptor binding protein in activating the viral fusion process during infection. By identifying the mechanism of fusion activation, we have now have identified promising targets for interfering with the viral entry process.
The lab is organized around the interdisciplinary theme of virus-host interactions. Projects draw from strategies and methods of molecular biology, cell biology, biophysics, immunology, computational biology, structural biology, and virology. Projects are inter-related in ways that lead to constant communication and contributions to scientific development.
The lab is organized around the interdisciplinary theme of virus-host interactions. Projects draw from strategies and methods of molecular biology, cell biology, biophysics, immunology, computational biology, structural biology, and virology. Projects are inter-related in ways that lead to constant communication and contributions to scientific development.
研究兴趣
论文共 201 篇作者统计合作学者相似作者
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JOURNAL OF VIROLOGY (2024)
JOURNAL OF VIROLOGYno. 1 (2024): e0179123-e0179123
Angela L Rasmussen, Gigi K Gronvall,Anice C Lowen,Felicia Goodrum,James Alwine,Kristian G Andersen,Simon J Anthony,Joel Baines, Arinjay Banerjee,Andrew J Broadbent, Christopher B Brooke,Samuel K Campos,
Journal of virologyno. 3 (2024): e0007424-e0007424
Springer eBookspp.1-50, (2023)
Olivier Reynard,Mathieu Iampietro,Sandrine Le Guellec,Marie Moroso, Stephanie Durand, Elise Brisebard,Cyrille Mathieu,Christopher Alabi,Laurent Vecellio,Maria Cabrera,Deborah Le Pennec, Mateo Porotto,
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERYno. 6 (2023): A32-A33
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Tara C Marcink,Gillian Zipursky, Wenjing Cheng,Kyle Stearns, Shari Stenglein,Kate Golub, Frances Cohen,Francesca Bovier,Daniel Pfalmer,Alexander L Greninger,Matteo Porotto,Amedee des Georges,
Ksenia Rybkina,Joseph N. Bell,Marissa C. Bradley,Teddy Wohlbold, Marika Scafuro,Wenzhao Meng, Rebecca C. Korenberg,Julia Davis-Porada,Brett R. Anderson,Rachel J. Weller,Joshua D. Milner,Anne Moscona,
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Olivier Reynard, Claudia Gonzalez,Claire Dumont,Mathieu Iampietro,Marion Ferren,Sandrine Le Guellec,Lajoie Laurie,Cyrille Mathieu, Gabrielle Carpentier,Georges Roseau,Francesca T. Bovier,Yun Zhu,
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