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Vertebrate blood vessels form stereotyped, hierarchical branched networks. Specialized endothelial cells (EC) called tip cells located at the extremities of growing capillary sprouts mediate their directional outgrowth. Following behind tip cells, other EC termed stalk cells form the capillary lumen and proliferate. Specific gene expression profiles in tip and stalk cells allow them to acquire their characteristic morphological features. Tip cells also show similarities to axonal growth cones and express receptors for axon guidance cues. Research in my lab is aimed at understanding the function of tip cell-specific signaling molecules, with the goal to manipulate guided vascular patterning. Another focus in the laboratory is to understand functions of vascular endothelial growth factors in the nervous system.
Specialized Terms: Vascular development and angiogenesis; Guidance of vascular patterning; Tip cells; Axonal growth cones; Vascular growth factors in the nervous system
Vertebrate blood vessels form stereotyped, hierarchical branched networks. Specialized endothelial cells (EC) called tip cells located at the extremities of growing capillary sprouts mediate their directional outgrowth. Following behind tip cells, other EC termed stalk cells form the capillary lumen and proliferate. Specific gene expression profiles in tip and stalk cells allow them to acquire their characteristic morphological features. Tip cells also show similarities to axonal growth cones and express receptors for axon guidance cues. Research in my lab is aimed at understanding the function of tip cell-specific signaling molecules, with the goal to manipulate guided vascular patterning. Another focus in the laboratory is to understand functions of vascular endothelial growth factors in the nervous system.
Specialized Terms: Vascular development and angiogenesis; Guidance of vascular patterning; Tip cells; Axonal growth cones; Vascular growth factors in the nervous system
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