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Autoimmune diseases such as Type 1 diabetes are increasing in incidence in the developed world faster than can be acounted for by genetic change. Onset of Type 1 diabetes and most other autoimmune diseases is governed by both genetic and environmental factors. Our study of environmental factors has highlighted a key role for infection in reducing the incidence of Type 1 diabetes. We find that protection from diabetes arises through an interaction between the infectious agent and the innate immune system such that circuits which regulate the autoimmune response are reinforced. These studies are carried out in collaboration with Professor D Dunne (Microbiology and Parasitology) and Dr P Mastroeni at the Vet School.
Many genes influence the development of Type 1 diabetes. While some genes such as those encoding MHC class II molecules play a major role other genes have been more difficult to identify. Dr Jenny Nichols and I have generated NOD ES cells and these will be used to identify and characterise genes involved in diabetes development in NOD mice.
Many genes influence the development of Type 1 diabetes. While some genes such as those encoding MHC class II molecules play a major role other genes have been more difficult to identify. Dr Jenny Nichols and I have generated NOD ES cells and these will be used to identify and characterise genes involved in diabetes development in NOD mice.
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The Journal of Immunologyno. 6 (2022): 1512-1512
FRONTIERS IN IMMUNOLOGY (2022): 852963-852963
Asha Recino,Kerry Barkan,Anja Schmidt-Christensen,Julia Nilsson,Nick Holmes,Duncan Howie,Dan Holmberg,Pär Larsson,Malin Flodström-Tullberg,Luca Laraia,David R Spring, Jacob Hecksher-Sørensen,
BioRxivpp.845776-34, (2019)
Andrea Cossarizza,Hyun-Dong Chang,Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam-Klages, William W. Agace, Nima Aghaeepour,Muebeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi,
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