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Dr. Nieminen has a long-standing interest in research related to mechanisms of mitochondrial dysfunction and its relevance to the treatment of GI and other cancers. Her research has employed various models of oxidative stress, photodynamic therapy, sensitization of pancreatic cancer to conventional chemotherapy, and the application of nanoparticles to treat head and neck cancers.
Her most recent research focuses on iron-mediated mitochondrial dysfunction related to liver injury.
Mitochondria are the site of biosynthesis of both iron-bound heme and non-heme iron sulfur clusters central to oxidative phosphorylation and mitochondrial bioenergetics. Despite its vital role in mitochondrial function and in reactive oxygen species (ROS) generation, mitochondrial iron levels must be tightly regulated to provide sufficient supply of iron for processes for which iron is a co-factor while at the same time preventing catalytic formation of toxic hydroxyl radicals. These hydroxyl radicals are highly damaging to DNA, proteins and membranes. Substantial evidence implicates mitochondrial iron as an important contributor to liver pathology, including acetaminophen toxicity, ischemia-reperfusion injury, oxidative stress, and iron overload in hemochromatosis.
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Journal of Cellular Physiologyno. 2 (2005)
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