基本信息
浏览量:18
职业迁徙
个人简介
In addition to studying mechanisms of HGT, we have also exploited this process to develop a novel method for multiplexed genome editing by natural transformation (MuGENT). This method allows for "accelerated evolution" of microbes through the integration of multiple unlinked fragments of DNA into the bacterial genome in a single step. This increases the pace of genetic studies, but also allows us to probe biological questions that were previously genetically intractable. We are currently employing this method to dissect the biology of bacterial pathogens, including V. cholerae. MuGENT also allows for rapid metabolic and phenotypic engineering of microbes, which we will employ to develop non-pathogenic naturally competent species for novel biotechnology applications.
We use genome-wide approaches (Tn-seq, RNA-seq, ChIP-seq, etc.), comparative genomics, genetics, molecular biology, microscopy, flow activated cell sorting (FACS), and biochemistry to achieve these goals.
We use genome-wide approaches (Tn-seq, RNA-seq, ChIP-seq, etc.), comparative genomics, genetics, molecular biology, microscopy, flow activated cell sorting (FACS), and biochemistry to achieve these goals.
研究兴趣
论文共 73 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2023)
biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2022)
biorxiv(2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn