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个人简介
My laboratory is involved in the study of the molecular mechanisms at the basis of motor neuron diseases (MNDs). Our main focus is on two forms of MNDs named spinal and bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), which are associated to the formation of aberrant mutant protein conformations that, for this, become neurotoxic. Our major aims are those to boost the intracellular protein quality control system to clear neurotoxic protein from affected neuronal cells. We recently identified a protective effect of a small heat shock protein (HSPB8) in the two diseases. This action seems to be mediated by the activation of autophagy.
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Elena Casarotto, Daisy Sproviero, Stella Gagliardi,Fabrizio Fabbiano,Barbara Tedesco,Riccardo Cristofani, Veronica Ferrari,Marta Chierichetti, Paola Rusmini,Mariarita Galbiati, Vito G D’Agostino, Katia Cortese,
semanticscholar(2020)
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D-Core
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