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Dr. Burger was a gifted researcher whose efforts helped ensure that work in the lab could swiftly reach patients. She contributed to significant advances in the treatment of Triple Negative Breast Cancer, one of the most aggressive forms of invasive breast cancer.
She worked as part of a team involving researchers from Karmanos, Cardiff University in Great Britain and the Sunnybrook Research Institute in Toronto to design a series of compounds based on Disulfiram -- typically used to treat alcoholism -- and found that one of the compounds was more potent than DSF itself in inhibiting an enzyme that spurs the growth of breast cancers. More than 50 percent of invasive breast cancers have the presence of the enzyme that could be treated by the DSF-derived compound.
She worked as part of a team involving researchers from Karmanos, Cardiff University in Great Britain and the Sunnybrook Research Institute in Toronto to design a series of compounds based on Disulfiram -- typically used to treat alcoholism -- and found that one of the compounds was more potent than DSF itself in inhibiting an enzyme that spurs the growth of breast cancers. More than 50 percent of invasive breast cancers have the presence of the enzyme that could be treated by the DSF-derived compound.
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论文共 4 篇作者统计合作学者相似作者
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S. M. Gadgeel,J. C. Ruckdeschel,A. J. Wozniak, W. Chen, D. Hackstock, C. Galasso,A. Burger,S. P. Ivy,P. Lorusso,M. J. Edelman
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D-Core
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