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We aim to define the molecular basis of cell fate decisions during human embryonic development through the use of human pluripotent stem cells (hPSCs). We focus particularly on the in vitro modelling of the events guiding the “birth” of the spinal cord and trunk musculature from a common precursor population known as Neuromesodermal Progenitors (NMPs) during embryonic axis elongation.
We are also interested in another multipotent embryonic progenitor population known as the neural crest (NC). Depending on their position along the anteroposterior (A-P) axis, NC cells give rise to various specialised cell types, such as peripheral neurons, neuroendocrine cells and skeletal cells in the head. We have defined the culture conditions directing the generation of NMPs from hPSCs as well as their differentiation into either neural or mesodermal cells (Gouti, Tsakiridis et al., 2014 PloS Biology; Frith et al. 2018 eLife). We have also established efficient protocols for the in vitro production of human NC cells corresponding to most A-P levels and found a close link between NMPs and the precursors of trunk NC cells (Frith et al. 2018 eLife).
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论文共 47 篇作者统计合作学者相似作者
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Ingrid M Saldana-Guerrero,Luis F Montano-Gutierrez, Katy Boswell,Christoph Hafemeister, Evon Poon,Lisa E Shaw,Dylan Stavish, Rebecca A Lea, Sara Wernig-Zorc,Eva Bozsaky,Irfete S Fetahu, Peter Zoescher,
Nature communicationsno. 1 (2024): 3745-3745
Fay Cooper,Anestis Tsakiridis
DEVELOPMENTno. 3 (2024)
Fay Cooper,Celine Souilhol, Scott Haston,Shona Gray, Katy Boswell, Antigoni Gogolou,Thomas J. R. Frith, Dylan Stavish, Bethany M. James,Daniel Bose, Jacqueline Kim Dale,Anestis Tsakiridis
DEVELOPMENTno. 3 (2024)
CANCER RESEARCHno. 7 (2023)
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medRxiv (Cold Spring Harbor Laboratory) (2023)
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Ingrid M. Saldana-Guerrero,Luis Fernando Montaño-Gutierrez,Christoph Hafemeister,Dylan Stavish,Lisa E. Shaw,Irfete S. Fetahu,Andrea Wenninger-Weinzierl,Caterina Sturtzel,Céline Souilhol, Sophia Tarelli,Mohamed R. Shoeb,Marie Bernkopf,
Cancer Researchno. 7_Supplement (2023): 3542-3542
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Rahman Sabahi Kaviani, Marina Shiryaeva,Celine Souilhol,Matthew Wind,Anestis Tsakiridis,Regina Luttge
TISSUE ENGINEERING PART Ano. 13-14 (2023)
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biorxiv(2022)
crossref(2022)
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