基本信息
浏览量:29
职业迁徙
个人简介
However, he is best known for his studies on the molecular mechanism and role of the mitochondrial permeability transition pore that is now accepted to play a critical role in cell death. The widely accepted molecular mechanism for this pore was first proposed by him and he has subsequently provided extensive evidence to support this important concept. He also pioneered studies on the role played by the MPTP in reperfusion injury, and the extent of MPTP opening is now recognised as a major determinant in the recovery of the heart and brain from ischaemia. He was the first to demonstrate protection of both the heart and brain from reperfusion injury by inhibitors of MPTP opening, and has subsequently identified a range of protective regimes involving inhibition of pore opening that are leading to improvements of the cardioplegic solutions and perfusion protocols used in cardiac surgery.
研究兴趣
论文共 333 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
biorxiv(2021)
bioRxiv (Cold Spring Harbor Laboratory) (2021)
Gonçalo C Pereira,Laura Lee,Nadiia Rawlings, Joke Ouwendijk, Joanne E Parker,Tatyana N Andrienko,Jeremy M Henley,Andrew P Halestrap
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn