Souers Andrew J - Small Mol Therapeut & Platform Technol, AbbVie Inc

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DDDR-40. TARGETING BCL-XL WITH MIRZOTAMAB CLETUZOCLAX (ABBV-155) AND STANDARD OF CARE THERAPIES OVERCOMES APOPTOTIC RESISTANCE IN GLIOBLASTOMA

Elizabeth Fernandez,Wilson Mai, Pauline Young, William Young,Fausto Rodriguez,Andrew Souers,Timothy Cloughesy,David Nathanson

Neuro-Oncologyno. Supplement_8 (2024)

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Abbv-453: A Highly Potent and Selective Next Generation Small Molecule Inhibitor of BCL-2

Darren C Phillips, Luzivette Robles-Cardona, Cory Alvey, Justin Ingram,Lloyd T Lam, Ziping Yang,Jacob J Riehm, Jun Chen, Matthew Kurnick,Peter Kovar,Jin Wang,George Doherty, Vikram Bhat,Yujia Dai, Andrew Judd,Andrew Souers

Bloodno. Supplement 1 (2024): 4966-4966

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Anti-Leukemia Combinatorial Efficacy of ABBV155, a B7H3-BCL-XL Inhibitor Antibody-Drug Conjugate, in Combination with Venetoclax Through BCL-XL/BIM and BCL-2/BIM Complex Dissociations

Zhe Wang,Cassandra L. Ramage,Helen Ma,Haichao Zhang,Andrew Souers,Darren C Phillips,Marina Konopleva, Qi Zhang Tatarata

Bloodno. Supplement 1 (2024): 2760-2760

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Androgen Deprivation-Induced Senescence Confers Sensitivity to a Senolytic Strategy in Prostate Cancer

Valerie Carpenter,Tareq Saleh,Eesha Chakraborty, So Min Lee,Graeme Murray,Jason Reed,Andrew Souers,Anthony C. Faber,Hisashi Harada,David A. Gewirtz

BIOCHEMICAL PHARMACOLOGY (2024)

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Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling

Wei Li,Renata Sano,Mutiah Apatira,Felix Deanda,Tarikere Gururaja, Muhua Yang, Greta Lundgaard, Chin Pan, Jing Liu,Yongjiao Zhai, Woo Hyun Yoon, Longcheng Wang,Chris Tse,Andrew J. Souers, Chih-Hung Lee

MOLECULAR CANCER THERAPEUTICS（2024）

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TARGETING BCL-XL WITH MIRZOTAMAB CLETUZOCLAX (ABBV-155) AND STANDARD OF CARE THERAPIES OVERCOMES APOPTOTIC RESISTANCE IN GLIOBLASTOMA

Elizabeth Fernandez,Wilson Mai, Pauline Young, William Young,Fausto Rodriguez,Andrew Souers,Timothy Cloughesy,David Nathanson

NEURO-ONCOLOGY (2024)

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BCL-XL-targeting Antibody-Drug Conjugates Are Active in Preclinical Models and Mitigate On-Mechanism Toxicity of Small-Molecule Inhibitors

Andrew S. Judd,Bhupinder Bawa,Wayne R. Buck,Zhi-Fu Tao,Yingchun Li,Michael J. Mitten,Milan Bruncko,Nathaniel Catron,George Doherty,Kenneth R. Durbin,Brian Enright,Robin Frey,Deanna Haasch, Sandra Haman, Anthony R. Haight, Tracy A. Henriques, James Holms, Kamel Izeradjene,Russell A. Judge,Gary J. Jenkins,Aaron Kunzer,Joel D. Leverson,Ruth L. Martin, Diya Mitra,Scott Mittelstadt, Lorne Nelson,Paul Nimmer,Joann Palma,Richard Peterson,Darren C. Phillips,Sherry L. Ralston,Saul H. Rosenberg, Xiaoqiang Shen,Xiaohong Song, Kedar R. Vaidya,Xilu Wang, Jin Wang,Yu Xiao,Haichao Zhang, Xinxin Zhang,Eric A. Blomme,Erwin R. Boghaert,John C. Kalvass,Andrew Phillips,Andrew J. Souers

SCIENCE ADVANCES（2024）

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Integrated Molecular and Functional Characterization of the Intrinsic Apoptotic Machinery Identifies Therapeutic Vulnerabilities in Glioma

Elizabeth G. Fernandez,Wilson X. Mai,Kai Song,Nicholas A. Bayley,Jiyoon Kim,Henan Zhu,Marissa Pioso, Pauline Young, Cassidy L. Andrasz,Dimitri Cadet,Linda M. Liau, Gang Li,William H. Yong,Fausto J. Rodriguez,Scott J. Dixon,Andrew J. Souers, Jingyi Jessica Li,Thomas G. Graeber,Timothy F. Cloughesy,David A. Nathanson

NATURE COMMUNICATIONS（2024）

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CSIG-04. INTEGRATED MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF THE INTRINSIC APOPTOTIC MACHINERY IDENTIFIES A DIAGNOSTICALLY INFORMED THERAPEUTIC APPROACH FOR MALIGNANT GLIOMA

Elizabeth Fernandez,Wilson Mai,Kai Song,Nicholas Bayley,Jiyoon Kim,Henan Zhu,Linda Liau,Gang Li,William Yong,Andrew Souers,Jingyi Jessica Li,Thomas Graeber,Timothy Cloughesy,David Nathanson

NEURO-ONCOLOGY (2023)

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Figure S8 from the Ewing Family of Tumors Relies on BCL-2 and BCL-XL to Escape PARP Inhibitor Toxicity

Daniel A.R. Heisey,Timothy L. Lochmann,Konstantinos V. Floros,Colin M. Coon,Krista M. Powell,Sheeba Jacob,Marissa L. Calbert,Maninderjit S. Ghotra,Giovanna T. Stein,Yuki Kato Maves,Steven C. Smith,Cyril H. Benes,Joel D. Leverson,Andrew J. Souers,Sosipatros A. Boikos,Anthony C. Faber

openalex（2023）

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