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个人简介
My interest in HLA has included non-classical HLA molecules and their relativesm in particular CD1 and recently the HLA-E. In 1988 Veronique Braud in my group showed that HLA-E bound to a conserved nonamer peptide derived from the signal sequence of classical HLA class I molecules and that this was recognised by the NKG2A/C receptors on natural killer cells, regulating their function. In 2016, we joined a collaboration with Louis Picker and colleagues at OHSU, who had shown that T cells stimulated in rhesus macaques by a cytomegalovirus vectored SIV vaccine are HLA-E restricted. These T cells are able to clear acute SIV infection in approximately 50% of animals after virus challenge. This led us (Geraldine Gillespie, Simon Brackenridge, Lucy Walters, Max Quastel) to explore how HLA-E binds a broad range of peptides, some in an atypical fashion, determining their molecular structures. Using in vitro priming techniques, we (Hongbing Yang, Hong Sun) have been able to demonstrate human CD8 T cells specific for HIV, SARS Coronavirus-2 and self antigenic peptides presented by HLA-E. We are currently working on virus specific and tumour specific HLA-E restricted T cells with an interest in developing immuno-therapies that could be applied universally because of the very limited polymorphism of HLA-E.
研究兴趣
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Milton Maciel Jr, Rama R. Amara,Katharine J. Bar,Shane Crotty,Steven G. Deeks, Christopher Duplessis,Gaurav Gaiha,M. Juliana McElrath,Andrew McMichael, Amy Palin,Rachel Rutishauser,Stuart Shapiro,
Frontiers in immunology (2024): 1329032-1329032
Nature Reviews Immunologyno. 4 (2023): 265-265
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NATURE COMMUNICATIONSno. 1 (2023)
Nature Communicationsno. 1 (2023)
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Zhansong Lin,Arman A. Bashirova,Mathias Viard,Lee Garner,Max Quastel,Maya Beiersdorfer,Wojciech K. Kasprzak, Marjan Akdag,Yuko Yuki, Pedro Ojeda,Sudipto Das,Thorkell Andresson,
The Journal of experimental medicineno. 8 (2023)
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NATURE REVIEWS IMMUNOLOGYno. 4 (2023): 265-265
Science immunologyno. 84 (2023)
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