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Physiology
The skin plays an essential role, mediated in part by its remarkable vascular plasticity, in adaptation to environmental stimuli. When established, primary HTN is characterized by increased peripheral vascular resistance (PVR). Increased PVR includes altered vascular resistance in the skin, evident at an early stage in primary HTN. Research Focus: To determine the factors relevant to the regulation of PVR in HTN, we chose the epidermis as a target tissue for manipulation of a key element in vascular function, the hypoxia-inducible transcription factor (HIF).
Physiology
The skin plays an essential role, mediated in part by its remarkable vascular plasticity, in adaptation to environmental stimuli. When established, primary HTN is characterized by increased peripheral vascular resistance (PVR). Increased PVR includes altered vascular resistance in the skin, evident at an early stage in primary HTN. Research Focus: To determine the factors relevant to the regulation of PVR in HTN, we chose the epidermis as a target tissue for manipulation of a key element in vascular function, the hypoxia-inducible transcription factor (HIF).
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biorxiv(2023)
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ARTHRITIS & RHEUMATOLOGYno. 1 (2023): 84-97
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Adam Fellows, Chien-Nien Chen, Chengyu Xie, Nayana Iyer,Lukas Schmidt,Xiaoke Yin,Manuel Mayr,Andrew S. Cowburn,Lan Zhao,Beata Wójciak-Stothard
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Encyclopedia of Respiratory Medicinepp.200-206, (2022)
American journal of respiratory and critical care medicineno. 8 (2022): 903-916
Arthritis & Rheumatology (2022)
British journal of pharmacologyno. 1 (2021): 121-131
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