基本信息
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职业迁徙
个人简介
Fields of Study
Biological and Organic Chemistry
Areas of Interest
Our research lies at the interface of chemistry and biology, with focus on constructing small molecule probes to understand and treat various types of cancers. We are interested in developing fluorescence-based assays that can rapidly and accurately predict anticancer drug resistance and aid in the discovery of novel inhibitors for cancer therapy. Some examples include enzymes involved in epigenetic, cell death inhibition and DNA repair pathways. We are also interested in developing cancer treatment platforms that do not share the same resistive mechanisms and long-term side effects as with current therapies. Specifically, our lab will develop enzyme-activatable photosensitizers that permit selective destruction and real-time imaging of cancer cells over normal cells. We will also engage in coupling photodynamic therapy with fluorescence-guided resection in order to reduce cancer recurrence post-surgery.
Biological and Organic Chemistry
Areas of Interest
Our research lies at the interface of chemistry and biology, with focus on constructing small molecule probes to understand and treat various types of cancers. We are interested in developing fluorescence-based assays that can rapidly and accurately predict anticancer drug resistance and aid in the discovery of novel inhibitors for cancer therapy. Some examples include enzymes involved in epigenetic, cell death inhibition and DNA repair pathways. We are also interested in developing cancer treatment platforms that do not share the same resistive mechanisms and long-term side effects as with current therapies. Specifically, our lab will develop enzyme-activatable photosensitizers that permit selective destruction and real-time imaging of cancer cells over normal cells. We will also engage in coupling photodynamic therapy with fluorescence-guided resection in order to reduce cancer recurrence post-surgery.
研究兴趣
论文共 28 篇作者统计合作学者相似作者
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Organic & biomolecular chemistry (2024)
Seylan Ayan,Adrian M. Rotaru, Esther G. Kaye, Gabrielle Juneau, Sunit Das, Christopher J. Wilds,Andrew A. Beharry
ORGANIC & BIOMOLECULAR CHEMISTRYno. 14 (2024): 2749-2753
Karishma Kailass,Dominick Casalena, Lina Jenane, Gregor McEdwards,Douglas S Auld,Oleg Sadovski, Esther G Kaye, Elyse Hudson, David Nettleton,Mark A Currie,Andrew A Beharry
Journal of medicinal chemistryno. 3 (2024): 2019-2030
The Journal of organic chemistryno. 15 (2023): 10655-10661
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Esther G Kaye,Bijan Mirabi, Ivonne R Lopez-Miranda,Komadhie C Dissanayake,Upasana Banerjee, Madelyn Austin,Mark Lautens,Arthur H. Winter,Andrew A. Beharry
Journal of the American Chemical Societyno. 23 (2023): 12518-12531
Esther G. G. Kaye,Bijan Mirabi, Ivonne R. R. Lopez-Miranda,Komadhie C. C. Dissanayake,Upasana Banerjee, Madelyn Austin,Mark Lautens,Arthur H. H. Winter,Andrew A. A. Beharry
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 23 (2023): 12518-12531
Esther G. G. Kaye,Bijan Mirabi, Ivonne R. R. Lopez-Miranda,Komadhie C. C. Dissanayake,Upasana Banerjee, Madelyn Austin,Mark Lautens,Arthur H. H. Winter,Andrew A. A. Beharry
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 23 (2023): 12518-12531
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Elyse M. Digby,Seylan Ayan,Pradeep Shrestha, Elizabeth J. Gehrmann,Arthur H. Winter,Andrew A. Beharry
JOURNAL OF MEDICINAL CHEMISTRYno. 24 (2022): 16679-16694
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