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个人简介
My formal training as a molecular neuroscientist began at Washington University, where I developed a long-lived fascination for understanding how experience (i.e., activity) and genes interact during neurodevelopment to influence the plastic properties of synapses and neurocircuits. Research at the Section on Molecular Neurobiology (SMN) initially focused on understanding how distinct patterns of motorneuron activity regulate the adaptive properties of skeletal muscles, and we were the first to identify cis- and trans-acting transcriptional elements that regulate slow- or fast-twitch skeletal muscle genes specifically in response to either slow and fast patterns of electrical stimulation. More recently, our group has investigated the activity-dependent functions of the Neuregulin (NRG) family of neurotrophic factors and their receptor ErbB4, both of which have been associated with a risk for schizophrenia. We have made major contributions demonstrating how the NRG-ErbB4 signaling pathway regulates synaptic plasticity, neuronal synchrony (gamma oscillations), dopamine signaling and behaviors in mutant mice that are associated with brain structures and traits affected in schizophrenia, autism and Alzheimer’s disease. In 2001 Dr. Buonanno was inducted as a member of the Latin American Academy of Sciences (ACAL).
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