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个人简介
The main focus of Dr. Osterman’s research team is on fundamental and applied aspects of the key metabolic subsystems in a variety of species, from bacteria to human. This group uses a systems biology approach to reconstruct and explore metabolic and transcriptional regulatory networks. This approach combines comparative genomics and other bioinformatic techniques with biochemical and genetic experiments for pathway, gene and target discovery. Using this approach this group predicted and experimentally verified numerous enzyme families in the metabolism of cofactors, carbohydrates, and amino acids. Recent breakthroughs included prediction and characterization of novel transporters, transcriptional regulators and carbohydrate utilization pathways in a number of model bacterial systems. Applications in the field of infectious disease include identification of novel drug targets and structure-based development of novel anti-infective agents. New directions in cancer research are based on application of metabolic profiling technology for identification of novel diagnostic and therapeutic targets. Other directions of the on-going research include bioinformatics of regulatory proteolysis and applications of structural modeling for exploration of metabolic networks and gene discovery.
研究兴趣
论文共 127 篇作者统计合作学者相似作者
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Claudia Zampaloni,Patrizio Mattei,Konrad Bleicher,Lotte Winther, Claudia Thäte, Christian Bucher,Jean-Michel Adam, Alexander Alanine,Kurt E. Amrein,Vadim Baidin,Christoph Bieniossek,Caterina Bissantz,
Ximena Diaz Olea, Kristin Beede,Andrei Osterman,David Scott, Christopher Petucci, Daniel Kelly, Amanda Ramer-Tait, Ze’ev A. Ronai
Cancer Researchno. 6_Supplement (2024): 6685-6685
Semen A. Leyn,James E. Kent,Jaime E. Zlamal, Marinela L. Elane, Maarten Vercruysse,Andrei L. Osterman
npj Antimicrobials and Resistanceno. 1 (2024): 1-11
Hao-Wei Chang, Evan M. Lee,Yi Wang,Cyrus Zhou, Kali M. Pruss, Suzanne Henrissat,Robert Y. Chen, Clara Kao,Matthew C. Hibberd,Hannah M. Lynn,Daniel M. Webber, Marie Crane,
CANCER RESEARCH COMMUNICATIONSno. 11 (2023): 2256-2267
Matthew C Hibberd,Daniel M Webber,Dmitry A Rodionov, Suzanne Henrissat,Robert Y Chen,Cyrus Zhou,Hannah M Lynn,Yi Wang,Hao-Wei Chang, Evan M Lee, Janaki Lelwala-Guruge,Marat D Kazanov,
Katerina I. Leonova,Anatoli S. Gleiberman, Victor Jaravine, Nicholas Trageser, Ksenia A. Novototskaya-Vlasova, Marina P. Antoch,Oleg V. Kurnasov,Andrei L. Osterman,Ekaterina L. Andrianova,Andrei V. Gudkov
Research Square (Research Square) (2023)
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Proceedings of the National Academy of Sciences of the United States of Americano. 39 (2023): e2311422120-e2311422120
Semen A. Leyn,James E. Kent,Jaime E. Zlamal, Marinela L. Elane, Maarten Vercruysse,Andrei L. Osterman
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Zachary W. Beller,Darryl A. Wesener, Timothy R. Seebeck,Janaki L. Guruge,Alexandra E. Byrne, Suzanne Henrissat,Nicolas Terrapon,Bernard Henrissat,Dmitry A. Rodionov,Andrei L. Osterman, Chris Suarez, Nikita P. Bacalzo Jr,
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