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He works on the molecular basis of immunological memory and its role in immunopathology.
Initially he showed that antibody class switching in B Lymphocytes is based on targeted recombination affecting the expressed and the silenced igh-genes. He showed that targeting of switch recombination to distinct switch regions requires their transcription,regulated by cytokines, and processing of the transcripts. He originally defined long-lived plasma cells, their role in humoral memory and in autoimmune disease and developed a novel concept for plasma cell homeostasis. He developed technologies for intracellular cytokine staining and the isolation of living cells according to cytokine secretion and used them to define the molecular imprinting of functional memory in T cells.
Initially he showed that antibody class switching in B Lymphocytes is based on targeted recombination affecting the expressed and the silenced igh-genes. He showed that targeting of switch recombination to distinct switch regions requires their transcription,regulated by cytokines, and processing of the transcripts. He originally defined long-lived plasma cells, their role in humoral memory and in autoimmune disease and developed a novel concept for plasma cell homeostasis. He developed technologies for intracellular cytokine staining and the isolation of living cells according to cytokine secretion and used them to define the molecular imprinting of functional memory in T cells.
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论文共 1014 篇作者统计合作学者相似作者
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Zeitschrift für Rheumatologieno. 2 (2024): 85-86
Methods in Cell Biology (2024)
ZEITSCHRIFT FUR RHEUMATOLOGIEno. 1 (2024): 34-40
Zeitschrift fur Rheumatologieno. 2 (2024): 85-86
Autoimmunityno. 1 (2024): 2323563-2323563
Zeitschrift für Rheumatologieno. 2 (2024): 105-111
Zeitschrift fur Rheumatologieno. 2 (2023): 177
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ZEITSCHRIFT FUR RHEUMATOLOGIEno. 2 (2023): 177-177
Marina Bondareva,Lisa Budzinski,Pawel Durek,Mario Witkowski,Stefan Angermair,Justus Ninnemann,Jakob Kreye, Philine Letz,Marta Ferreira-Gomes, Iaroslav Semin,Gabriela Maria Guerra,S. Momsen Reincke,
CELL HOST & MICROBEno. 11 (2023): 1866-+
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