Andreas Jekle - Aligos Therapeutics, Inc

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论文共 81 篇作者统计合作学者相似作者

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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (Thr-Β) Agonist for the Treatment of MASH

Koen Vandyck,David C. Mcgowan,Xuan G. Luong,Sarah K. Stevens,Andreas Jekle,Kusum Gupta,Dinah L. Misner,Sushmita Chanda,Vladimir Serebryany, Michael Welch, Haiyang Hu, Zhidan Lv,Caroline Williams,Klaus Maskos,Alfred Lammens,Antitsa D. Stoycheva, Tse- Lin,Lawrence M. Blatt,Leonid N. Beigelman,Julian A. Symons,Pierre Raboisson,Jerome Deval

JOURNAL OF MEDICINAL CHEMISTRYno. 17 (2024): 14840-14851

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Non-HAP CAM-A ALG-006746 and ALG-006780 Induce Rapid HBsAg Reductions in AAV-HBV Mice and Have Favorable Pharmacokinetic Profiles

Hannah Vanrusselt, Jordi Verheyen,Kusum Gupta, Lars Degrauwe,Cheng Liu,Abel Acosta Sanchez, Melanie Bollier, Jean-Boris Nshimyumuremyi, Benjamin Verburgh, Clovis Peter,Qingling Zhang,Lawrence Blatt,Leonid Beigelman,Julian Symons,Sushmita Chanda,David Smith,Andreas Jekle,Sandrine Vendeville,David McGowan,Yannick Debing

JOURNAL OF HEPATOLOGY (2024): S728-S728

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The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075

Sandrine Vendeville,Franck Amblard,Leda Bassit,Leonid N. Beigelman,Lawrence M. Blatt,Xiaoyuan Chen, Lang Chou,Dieudonne Buh Kum,Sushmita Chanda,Jerome Deval, Xiu Geng,Kusum Gupta,Andreas Jekle, Haiyang Hu, Xiaojuan Hu,Hyunsoon Kang,Cheng Liu,Jyanwei Liu,David C. Mcgowan,Dinah L. Misner,Pierre Raboisson,Abel Acosta Sanchez,Vladimir Serebryany,Antitsa D. Stoycheva,Julian A. Symons,Hua Tan,Hannah Vanrusselt,Caroline Williams, Michael Welch, Liangliang Zhang,Qingling Zhang, Yafeng Zhang,Raymond F. Schinazi,David B. Smith,Yannick Debing

JOURNAL OF MEDICINAL CHEMISTRY（2024）

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TOP-358-YI Non-HAP CAM-A ALG-006746 and ALG-006780 Induce Rapid HBsAg Reductions in AAV-HBV Mice and Have Favorable Pharmacokinetic Profiles

Hannah Vanrusselt, Jordi Verheyen,Kusum Gupta, Lars Degrauwe,Cheng Liu,Abel Acosta Sanchez, Mélanie Bollier, Jean-Boris Nshimyumuremyi, Benjamin Verburgh, Clovis Peter,Qingling Zhang,Lawrence Blatt,Leonid Beigelman,Julian Symons,Sushmita Chanda,David Smith,Andreas Jekle,Sandrine Vendeville,David McGowan,Yannick Debing

Journal of Hepatology (2024): S728

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1341 Discovery and Preclinical Characterization of ALG-093940, a Potent and Orally Bioavailable Small Molecule PD-L1 Inhibitor for the Treatment of Cancer

Heleen Roose,Kristina Rekstyte-Matiene,Sarah Stevens,Kusum Gupta,Sandra Chang,Cheng Liu,Vladimir Serebryany, Lillian Adame,Kha Le,Antitsa Stoycheva,Dinah Misner,Lawrence M Blatt,Leonid Beigelman,Sushmita Chanda,David B Smith,Julian A Symons,Andreas Jekle,Tongfei Wu

Regular and Young Investigator Award Abstracts (2024)

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CAPSID ASSEMBLY MODULATORS SUCH AS ALG-001075 INDUCE PROFOUND HBV DNA KNOCKDOWN AND DIRECTLY TARGET HBEAG IN VITRO

Cheng Liu, Jordi Verheyen,Dieudonne Buh Kum,Hannah Vanrusselt,Tse-I Lin,Julian Symons,Lawrence Blatt,Andreas Jekle,Yannick Debing

HEPATOLOGY (2024): S211-S211

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Preclinical Pharmacokinetic, Pharmacodynamic and Efficacy Relationships of ALG-093702, a Liver Targeted PD-L1 Small Molecule Inhibitor, in Different in Vivo Models

Heleen Roose,Qingling Zhang,Kha Le,Andreas Jekle,Kristina Rekstyte-Matiene,Sarah Stevens,Ruchika Jaisinghani,Cheng Liu,Sandra Chang,Antitsa Stoycheva,Lawrence Blatt,Leonid Beigelman,Julian Symons,Sushmita Chanda,Francois Gonzalvez,Tongfei Wu

Journal of Hepatology (2023): S1030-S1031

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An in Vivo Duck Hepatitis B Virus Model Recapitulates Key Aspects of Nucleic Acid Polymer Treatment Outcomes in Chronic Hepatitis B Patients

Yannick Debing,Hannah Vanrusselt, Lars Degrauwe, Daniel Apolonio Silva de Oliveira,Christopher Kinyanjui Kariuki,Ebanja Joseph Ebwanga,Shahbaz Bashir, Wouter Merckx, Santhosh Kumar Thatikonda,Vivek Rajwanshi,Vikrant Gohil,Jin Hong,Dieudonne Buh Kum,Abel Acosta Sanchez,Sushmita Chanda,Lawrence M. Blatt,Andreas Jekle,Julian A. Symons,David B. Smith,Pierre Raboisson, Tse- Lin,Leonid Beigelman,Jan Paeshuyse

Journal of Hepatology（2023）

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1382 Discovery of ALG-094103, a Liver-Targeted and Orally Bioavailable Small Molecule PD-L1 Inhibitor for the Treatment of Liver Cancer

Cheng Liu,Sarah Stevens,Heleen Roose,Kha Le,Kristina Rekstyte-Matiene,Kusum Gupta,Sandra Chang,Vladimir Serebryany, Lillian Adame,Antitsa Stoycheva,Lawrence M Blatt,Leonid Beigelman,Sushmita Chanda,David B Smith,Julian A Symons,Andreas Jekle,Tongfei Wu

Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)

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