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One of the key challenges of understanding biological cells is trying to make rigorous and quantitative statements in the face of enormous model uncertainty: While we typically know some things about a cellular process we never know everything, which leaves mathematical models hugely under-determined and makes common modeling approaches unreliable.
The focus of our research is thus to study complex systems such as cellular processes, not by ignoring or guessing unknown details, but by deriving testable predictions that are provably independent of them. For example, specifying some features of a system while leaving everything else unspecified allows us to establish physical performance bounds for classes of intracellular processes such as feedback control.
Additionally, we develop theoretical tools to exploit naturally occurring cell-to-cell variability to test specific hypotheses within large reaction networks. For example, the network invariants we derived showed that mRNA-protein fluctuation data in E. coli contradict the majority of published models of stochastic gene expression.
The focus of our research is thus to study complex systems such as cellular processes, not by ignoring or guessing unknown details, but by deriving testable predictions that are provably independent of them. For example, specifying some features of a system while leaving everything else unspecified allows us to establish physical performance bounds for classes of intracellular processes such as feedback control.
Additionally, we develop theoretical tools to exploit naturally occurring cell-to-cell variability to test specific hypotheses within large reaction networks. For example, the network invariants we derived showed that mRNA-protein fluctuation data in E. coli contradict the majority of published models of stochastic gene expression.
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论文共 29 篇作者统计合作学者相似作者
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Raymond Fan,Andreas Hilfinger
Biophysical journalno. 5 (2023): 905-923
biorxiv(2023)
Analytical biochemistry (2023): 115182-115182
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Raymond Fan,Andreas Hilfinger
arXiv (Cornell University) (2023)
Krista Jager, Maria Teresa Orozco-Hildago,Benjamin L. Springstein,Euan Joly-Smith,Fotini Papazotos, EmilyKate McDonough,Eleanor Fleming,Giselle McCallum,Andreas Hilfinger,Ann Hochschild,Laurent Potvin-Trottier
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Euan Joly-Smith, Mir Mikdad Talpur, Paige Allard, Fotini Papazotos,Laurent Potvin-Trottier,Andreas Hilfinger
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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biorxiv(2023)
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