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Why is regeneration of adult human tissues so limited, when other vertebrates are readily able to regenerate complex tissues like the spinal cord, cartilage, and limb? Our goal is to define the genetic pathways and epigenetic mechanisms that govern differentiation of different cell types during regeneration and embryogenesis. We employ a combination of genomics, embryology and cell biology using the diploid frog Xenopus tropicalis as a model for regeneration. Tadpoles are able to rapidly regenerate tissues of the nervous system, musculature, cartilage and vasculature after injury, but lose this regeneration competence as metamorphosis progresses. We are interested in all aspects of regeneration, but two themes are of particular interest to the lab:
Why is regeneration of adult human tissues so limited, when other vertebrates are readily able to regenerate complex tissues like the spinal cord, cartilage, and limb? Our goal is to define the genetic pathways and epigenetic mechanisms that govern differentiation of different cell types during regeneration and embryogenesis. We employ a combination of genomics, embryology and cell biology using the diploid frog Xenopus tropicalis as a model for regeneration. Tadpoles are able to rapidly regenerate tissues of the nervous system, musculature, cartilage and vasculature after injury, but lose this regeneration competence as metamorphosis progresses. We are interested in all aspects of regeneration, but two themes are of particular interest to the lab:
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论文共 38 篇作者统计合作学者相似作者
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Kelly Jin, Brianah M McCoy,Elisabeth A Goldman, Viktoria Usova,Victor Tkachev,Alex D Chitsazan, Anneke Kakebeen,Unity Jeffery,Kate E Creevy,Andrea Wills,Noah Snyder-Mackler,Daniel E L Promislow
Aging cellno. 4 (2024): e14079-e14079
STAR PROTOCOLSno. 1 (2024): 102895-102895
Developmental cellno. 22 (2023): 2597-2613.e4
DEVELOPMENTAL CELLno. 22 (2023): 2597-+
SSRN Electronic Journal (2022)
Hannah E Arbach,Marcus Harland-Dunaway, Christopher Braden, Alexander D Chitsazan, Eleanor Pickering,Jeet H Patel,Andrea E Wills
Developmental biology (2021): 59-70
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