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个人简介
My research interest is developing new therapeutic agents for pancreatic cancer. The mammalian target of rapamycin (mTOR) is a downstream mediator in the phosphatidylinositol 3-kinase (PI3K) pathway that regulates cell proliferation, cell survival and angiogenesis in cancer. We hypothesize that combined blockade of the converging pathways can yield a better anti-tumor activity. Currently, we are in the process of examining the clinical benefit of double blockade with a phase I clinical study of the mTOR inhibitor and the EGFR inhibitor in recurrent/refractory malignancies. Furthermore, we are evaluating the potential predictive factors for treatment response and exploring the mechanism of treatment resistance.
研究兴趣
论文共 27 篇作者统计合作学者相似作者
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Max M. Wattenberg,Sarah Colby,Ignacio Garrido-Laguna, Yuqing Xue,Renee Chang,Devora Delman,Jesse Lee,Kajsa Affolter,Sean J. Mulvihill, M. Shaalan Beg,Andrea Wang-Gillam, James Lloyd Wade,
Gastroenterology (2024)
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Cancer Medicineno. 22 (2022): 4169-4181
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