基本信息
浏览量:2
职业迁徙
个人简介
My research goal is to identify novel therapeutic interventions for treating pain that lack abuse liability and adverse side effects. The discovery of cannabinoid receptors and identification of brain constituents that act at these receptors established the existence of an endogenous cannabis-like (endocannabinoid) transmitter system. My lab has focused on harnessing the therapeutic potential of the endocannabinoid signaling system to suppress neuropathic pain while minimizing unwanted side effects (i.e., psychoactivity and addiction). The endocannabinoid system consists of cannabinoid receptors (CB1 and CB2), endogenous ligands (endocannabinoids), and the enzymes catalyzing endocannabinoid synthesis and degradation. My lab has identified functional roles of the endocannabinoid system in the nervous system and mapped its distribution in sensory pathways. My research has identified enzymes implicated in endocannabinoid deactivation as novel therapeutic targets for pain and stress-related disorders. My laboratory strives to maximize the therapeutic potential of endocannabinoid signaling systems while minimizing unwanted central nervous system side effects (e.g., psychoactivity and addiction). My lab has also disrupted protein-protein interactions downstream of NMDA receptors to suppress pronociceptive signaling cascades without the adverse effects of NMDAR antagonists (i.e., by targeting interactions between neuronal nitric oxide synthase and its upstream [PSD95] or downstream [NOS1AP] protein partners). My laboratory combines approaches from behavioral pharmacology, neurophysiology, neuroanatomy, biochemistry, and molecular biology.
研究兴趣
论文共 147 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Joshua Watkins, Petra Aradi, Rachel Hahn,Istvan Katona,Ken Mackie,Alexandros Makriyannis,Andrea G Hohmann
bioRxiv : the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
Joshua M. Watkins, Petra Aradi, Rachel Hahn,Alexandros Makriyannis,Ken Mackie,Istvan Katona,Andrea G Hohmann
biorxiv(2024)
bioRxiv : the preprint server for biology (2024)
Vishakh Iyer,Shahin A Saberi,Romario Pacheco, Emily Fender Sizemore, Sarah Stockman,Abhijit Kulkarni,Lucas Cantwell,Ganesh A Thakur,Andrea G Hohmann
bioRxiv : the preprint server for biology (2024)
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt,Janos Paloczi, Avand Amedi,Richard J. B. H. N. van den Berg,Joerg Benz,Ludovic Collin,Hui Deng,Xinyu Di,Wouter F. Driever,Bogdan I. Florea,
NATURE COMMUNICATIONSno. 1 (2023)
Ming Jiang, Mirjam C W Huizenga, Jonah L Wirt,Janos Paloczi, Avand Amedi,Richard J B H N van den Berg,Joerg Benz,Ludovic Collin,Hui Deng,Xinyu Di,Wouter F Driever,Bogdan I Florea,
Nature communicationsno. 1 (2023): 8039-8039
Neuropharmacology (2023): 109601-109601
Hongwei Cai,Zheng Ao, Chunhui Tian,Zhuhao Wu, Connor Kaurich,Zi Chen, Mingxia Gu,Andrea G. Hohmann, Ken Mackie,Feng Guo
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn