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In the Bach Group, we develop biological active small-molecule inhibitors of protein-protein interactions involved in oxidative stress and which play key roles in inflammation and brain diseases (e.g. neurodegeneration and brain cancer). We evaluate the ‘druggability’ of selected targets, and aim at developing new high-quality chemical probes useful for pharmacological studies and for identifying new therapeutic principles against diseases.
Fragment-based drug discovery (FBDD) is a core theme of our research. We screen our library of fragments (i.e. small substructures of druglike molecules) using very sensitive biophysical methods, such as SPR and NMR. Promising and validated hits are optimized into lead molecules by medicinal chemistry, biostructural studies and pharmacology.
In the Bach Group, we develop biological active small-molecule inhibitors of protein-protein interactions involved in oxidative stress and which play key roles in inflammation and brain diseases (e.g. neurodegeneration and brain cancer). We evaluate the ‘druggability’ of selected targets, and aim at developing new high-quality chemical probes useful for pharmacological studies and for identifying new therapeutic principles against diseases.
Fragment-based drug discovery (FBDD) is a core theme of our research. We screen our library of fragments (i.e. small substructures of druglike molecules) using very sensitive biophysical methods, such as SPR and NMR. Promising and validated hits are optimized into lead molecules by medicinal chemistry, biostructural studies and pharmacology.
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论文共 97 篇作者统计合作学者相似作者
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Nicole Fadahunsi,Jonas Petersen,Sophia Metz, Alexander Jakobsen,Cecilie Vad Mathiesen, Alberte Silke Buch-Rasmussen, Nigel Kurgan,Jeppe Kjærgaard Larsen,Rita C Andersen, Thomas Topilko, Charlotte Svendsen, Mia Apuschkin,
Science advancesno. 9 (2024): eadg2636-eadg2636
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISMno. 8 (2023): 1419-1434
Drug Discovery Todayno. 6 (2023): 103575-103575
Christian B M Poulie,Camilla B Chan,Aleksandra Parka, Magnus Lettorp, Josephine Vos, Amanda Raaschou,Eline Pottie, Mikkel S Bundgaard,Louis M E Sørensen, Claudia R Cecchi,Emil Märcher-Rørsted,Anders Bach,
ACS pharmacology & translational scienceno. 10 (2023): 1492-1507
Jie Zang, Felix Peters,Yves Cambet,Eugenia Cifuentes-Pagano, Munira Mohamed Shishay Hissabu,Christopher M. Dustin, Lars Henrik Svensson, Martin Mariboe Olesen, Mathias Feldt Lomholt Poulsen, Stig Jacobsen, Pernille Sonderby Tuelung,Dilip Narayanan,
JOURNAL OF MEDICINAL CHEMISTRYno. 21 (2023): 14963-15005
Emma Lisa Al Humaidan, Sidse Lund Pedersen,Annette Burkhart,Charlotte Laurfelt Munch Rasmussen,Torben Moos, Peter Fuchs,Eduardo Filipe Alves Fernandes,Burak Ozgür,Kristian Strømgaard,Anders Bach,Birger Brodin,Mie Kristensen
Frontiers in Drug Delivery (2022)
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