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Alun Williams leads a research group whose current focus in determining the mechanism of neurodegeneration in chronic neurodegenerative diseases, particularly prion diseases such as Creutzfeldt-Jakob Disease, and also Alzheimer’s disease and Parkinson’s. For all these three peptides, the concentration required to cause synaptic damage in cultured neurons is 1/1000 that required to cause cell death – reflecting the pathogenesis of these diseases in vivo where synaptic loss occurs prior to cell death, and when concentrations of the toxic peptide in the affected areas of the brain are lower.
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Benjamin J. Butler,Thuy-Tien N. Nguyen,Alun Williams, Andrew Tucker,William G. Proud,Katherine A. Brown
Epj Web of Conferences (2021): 01024
Andrei Pissarenko,Wen Yang, Haocheng Quan, Boris Poyer,Alun Williams, Katherine A Brown,Marc A Meyers
Riyad Peeraully, Katrina Henderson, Kristina Fairbrother,Ramnik Patel,Nia Fraser,Manoj Shenoy,Alun Williams
Katherine A. Brown, Benjamin J. Butler,David Sory,Thuy-Tien N. Nguyen,Alun Williams,William G. Proud
AIP Conference Proceedings (2018)
Katherine A. Brown, Benjamin J. Butler, Thuy-Tien N. Nguyen, David Sorry,Alun Williams,William Proud
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