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Regenerative medicine seeks to develop advanced health technologies to regenerate or replace damaged and diseased tissues. During regeneration, a tissue is remodelled and replacement cells are recruited and re-organized into a specific arrangement. For example, during wound healing or regeneration replacement cells, often stem cells, are recruited and re-organized into a specific arrangement to generate new tissue. The functionality of the regenerated tissue depends critically on correct incorporation and re-organization of the cells during the regenerative process. Understanding how cell re-organization (termed morphogenesis) is regulated and how it can be controlled is a central problem in regenerative medicine. In contrast, in diseases, such as cancer, cells in the tissue re-organize incorrectly as the disease spreads. Understanding cell re-organization therefore could also provide a basis for identifying novel disease therapies. The objective of the McGuigan lab is to develop experimental systems to understand and control cellular morphogenesis for regenerative medicine applications.
Historically the signals that guide cell re-organization to produce tissue patterning have been studied extensively in developing embryos using various animal models. The complexity of embryo morphogenesis and the interplay between multiple signals at multiple length scales make this a particularly challenging process to dissect however, and animal models often do not easily allow combinations of different signals to be perturbed systematically. In vitro models (cell culture models) that allow systematic analysis of the signals that direct cell re-organization would be extremely valuable for carefully dissecting the rules that govern tissue morphogenesis. Furthermore, cell culture systems offer the potential for high-throughput screening to identify therapeutic strategies, such as drugs or biomaterials, for modulating and controlling the cell re-organization process.
Historically the signals that guide cell re-organization to produce tissue patterning have been studied extensively in developing embryos using various animal models. The complexity of embryo morphogenesis and the interplay between multiple signals at multiple length scales make this a particularly challenging process to dissect however, and animal models often do not easily allow combinations of different signals to be perturbed systematically. In vitro models (cell culture models) that allow systematic analysis of the signals that direct cell re-organization would be extremely valuable for carefully dissecting the rules that govern tissue morphogenesis. Furthermore, cell culture systems offer the potential for high-throughput screening to identify therapeutic strategies, such as drugs or biomaterials, for modulating and controlling the cell re-organization process.
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论文共 108 篇作者统计合作学者相似作者
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Saif Rjaibi,Erik Jacques, Caroline Ni,Bin Xu,Sonya Kouthouridis, Julie Sitolle,heta Lad,Nitya Gulati,Nancy T Li, Henry Ahn,Howard Ginsberg,Boyang Zhang,
biorxiv(2024)
Natalie Landon-Brace,Brendan T Innes,Simon Latour,Jose L Cadavid,Ileana L Co, Cassidy Tam, Ferris Nowlan, Sibyl Drissler,Faiyaz Notta,Hartland W Jackson,Gary D Bader,Alison P McGuigan
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Biophysics reviewsno. 2 (2024): 021301-021301
Daniel Lee,Simon Latour, Michael Emblem, Hunter J. Clark, Jobette T. Santos,Jaewan Jang,Alison P. Mcguigan,Mark Nitz
Nature Reviews Bioengineeringno. 12 (2023): 972-988
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Nitya Gulati,Sadegh Davoudi, Bai Xu,Saifedine T Rjaibi, Eric Jacques, Justin Pham,Amir Fard,Alison P. McGuigan,Penney M. Gilbert
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Nila C Wu,Rene Quevedo, Michelle Nurse,Kebria Hezaveh,Haijiao Liu, Fumao Sun,Julien Muffat,Yu Sun,Craig A Simmons,Tracy L McGaha,Panagiotis Prinos,Cheryl H Arrowsmith,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Nicole Potter,Simon Latour, Edmond C. N. Wong,Mitchell A. Winnik,Hartland W. Jackson,Alison P. Mcguigan,Mark Nitz
BIOCONJUGATE CHEMISTRYno. 1 (2023): 80-91
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