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The Lundby group works on a multitude of diverse projects, but the overarching aim of all projects is to identify specific proteins crucial for a given cardiac phenotype. Our projects are based on our combined expertise in high-resolution proteomics technology, cardiac ion channel research and human population genetics. We have previously shown that integration of quantitative interaction proteomics with human population genetics is a strong tool to uncover novel proteins associated with a cardiac phenotype. We are currently exploiting our expertise within this interdisciplinary approach to specifically untangle molecular players involved in the cardiac disorders atrial fibrillation and heart failure.
As many cardiac diseases are primarily associated with dysfunction of one of the four cardiac chambers we are also performing detailed investigations of the protein-specific differences among the four chambers. We believe this will be key information to identify novel pharmaceutical targets with chamber-specific impact.
The Lundby group works on a multitude of diverse projects, but the overarching aim of all projects is to identify specific proteins crucial for a given cardiac phenotype. Our projects are based on our combined expertise in high-resolution proteomics technology, cardiac ion channel research and human population genetics. We have previously shown that integration of quantitative interaction proteomics with human population genetics is a strong tool to uncover novel proteins associated with a cardiac phenotype. We are currently exploiting our expertise within this interdisciplinary approach to specifically untangle molecular players involved in the cardiac disorders atrial fibrillation and heart failure.
As many cardiac diseases are primarily associated with dysfunction of one of the four cardiac chambers we are also performing detailed investigations of the protein-specific differences among the four chambers. We believe this will be key information to identify novel pharmaceutical targets with chamber-specific impact.
研究兴趣
论文共 69 篇作者统计合作学者相似作者
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Konstantin Kahnert,Luca Soattin,Robert W Mills,Claire Wilson, Svetlana Maurya,Andrea Sorrentino, Sami Al-Othman, Roman Tikhomirov, Yordi J van de Vegte,Finn B Hansen, Jonathan Achter,Wei Hu,
Cardiovascular research (2024)
Svetlana Maurya, Robert W. Mills,Konstantin Kahnert, David Y. Chiang,Giorgia Bertoli, Pia R. Lundegaard,Marta Perez-Hernandez Duran, Mingliang Zhang,Eli Rothenberg, Alfred L. George Jr.,Calum A. MacRae, Mario Delmar,
Nature Cardiovascular Researchno. 7 (2023): 673-692
NATURE CARDIOVASCULAR RESEARCHno. 7 (2023): 611-612
MOLECULAR & CELLULAR PROTEOMICSno. 8 (2022): S27-S27
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Chantal J.M. van Opbergen,Alison Smith, Rakesh R. Maurya, Duk Jae Kim,Alison N. Smith, Darren J. Blackwell,Jeffrey N. Johnston,Bjorn C. Knollmann,Marina Cerrone,Alicia Lundby,Mario Delmar
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