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The over-arching goal of our research is to better understand the mechanisms of neurodegenerative disease in order to intervene in these disease processes.
Our general approach is to use unbiased genomic- or proteomic-scale screens in human-derived materials to generate leads, which are then followed mechanistically in relevant systems including neuronal culture and in vivo animal models. The pace of technology development is allowing us to acquire more data, faster, than ever before, but this does not always translate into biological understanding. We believe that to unlock the true potential of leads generated in this way, computational methods must work hand-in-hand with bench-based manipulative experiments.
Our general approach is to use unbiased genomic- or proteomic-scale screens in human-derived materials to generate leads, which are then followed mechanistically in relevant systems including neuronal culture and in vivo animal models. The pace of technology development is allowing us to acquire more data, faster, than ever before, but this does not always translate into biological understanding. We believe that to unlock the true potential of leads generated in this way, computational methods must work hand-in-hand with bench-based manipulative experiments.
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论文共 172 篇作者统计合作学者相似作者
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George Kannarkat,Rebecca Zack, Robert Skrinak,James Morley,Roseanne Davila-Rivera,Sanaz Arezoumandan, Katherine Dorfman, Kelvin Luk,Daniel Weintraub,Thomas Tropea,Edward Lee, Virginia Lee,
Anantharaman Shantaraman,Eric B Dammer, Obiadada Ugochukwu,Duc M Duong,Luming Yin,E Kathleen Carter,Marla Gearing,Alice Chen-Plotkin,Edward B Lee,John Q Trojanowski,David A Bennett,James J Lah,
bioRxiv : the preprint server for biology (2024)
Katheryn A Q Cousins, Jeffrey S Phillips,Sandhitsu R Das, Kyra O'Brien,Thomas F Tropea,Alice Chen-Plotkin,Leslie M Shaw,Ilya M Nasrallah,Dawn Mechanic-Hamilton,Corey T McMillan,David J Irwin,Edward B Lee,
Brain : a journal of neurology (2024)
JMIR bioinformatics and biotechnology (2023): e45370-e45370
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Dylan V Neel,Himanish Basu,Georgia Gunner, Matthew D Bergstresser,Richard M Giadone,Haeji Chung,Rui Miao,Vicky Chou, Eliza Brody,Xin Jiang,Edward Lee,Michelle E Watts,
ANNALS OF NEUROLOGYno. 5 (2023): 1045-1046
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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