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Alexei Verkhratsky is an internationally recognised scholar in the field of cellular neurophysiology, best known for his contributions to our knowledge of the physiology and pathophysiology of neuroglia. He was one of the first to discover the specific expression of neurotransmitter receptors in astrocytes and their activation in situ by physiological stimulation. He demonstrated (with H. Kettenmann) matching patterns of neuronal and glial receptors in situ, thus providing the basis for the concept of active and reciprocal neuronal-glial communications. He demonstrated that these receptors are connected to Ca2+ signalling cascades, which led to the important concept of glial Ca2+ excitability. He found a close relationship between Ca2+ and Na+ dynamics in astroglia and developed the concept of Na+ as a specific signalling molecule controlling local homeostatic responses of astrocytes. These discoveries have made a major contribution to the development of a new doctrine of the fundamental role of neuroglia in brain function. Verkhratsky also contributed to the emerging field of neurogliopathology; he characterised astroglial atrophy in the context of neurodegenerative diseases and proposed astrodegeneration as an early, key pathogenetic step in neurodegeneration. In a series of highly cited conceptual reviews (e.g. [1; 2]) he outlined basic principles of glial physiology and pathophysiology, which significantly influenced this rapidly developing area of neuroscience.
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NEURAL REGENERATION RESEARCHno. 9 (2024): 1887-1887
Cell Calcium (2024): 102872-102872
Cell death & diseaseno. 4 (2024): 258-258
FUNCTIONno. 2 (2024): zqae002-zqae002
Neural regeneration researchno. 4 (2024): 709-710
Shihe Jiang,Xindi Li,Yan Li, Zhilin Chang,Meng Yuan,Ying Zhang, Huimin Zhu,Yuwen Xiu,Hengri Cong,Linlin Yin,Zhen-Wei Yu,Junwan Fan,
SCIENCE TRANSLATIONAL MEDICINEno. 736 (2024): eadg5116-eadg5116
Acta physiologica (Oxford, England)no. 4 (2024): e14120-e14120
Maria Alejandra Gonzalez-Gonzalez,Silvia V. Conde, Ramon Latorre, Stephanie C. Thebault,Marta Pratelli,Nicholas C. Spitzer,Alexei Verkhratsky,Marie-Eve Tremblay, Cuneyt G. Akcora,Ana G. Hernandez-Reynoso,Melanie Ecker, Jayme Coates,
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