基本信息
浏览量:120
职业迁徙
个人简介
Small RNAs as determinants of epigenetic states
Gene silencing via the RNA interference (RNAi) pathway is an evolutionary conserved process that is critical for the control of gene expression in organisms ranging from yeast to humans. Targets of RNAi are recognized through complementary base-pairing interactions with small RNAs that act as guides to RNAi effector complexes. Several distinct classes of endogenous small RNAs, including microRNAs, endo-siRNAs and piRNAs, regulate gene expression states to impact diverse biological processes. Our lab focuses on understanding the nature and biological functions of small RNA pathways in animals. We have identified and characterized an evolutionary conserved small RNA pathway that operates in germ cells and that is critical both for germline stem cell maintenance and for gametogenesis. Working in Drosophila and mice, we discovered a new class of small RNAs, Piwi-interacting (pi)RNAs. Piwi/piRNA pathway plays an important role in genome integrity by repressing selfish repetitive elements. A characterization of piRNA sequences in combination with genetic studies revealed that the biogenesis and function of piRNAs differs from that of other classes of small RNAs. While canonical small RNAs, such as microRNAs, affect gene expression post-transcriptionally, our studies suggest that piRNAs most likely serve as guides for de novo DNA methylation in mouse male germ cells.
Gene silencing via the RNA interference (RNAi) pathway is an evolutionary conserved process that is critical for the control of gene expression in organisms ranging from yeast to humans. Targets of RNAi are recognized through complementary base-pairing interactions with small RNAs that act as guides to RNAi effector complexes. Several distinct classes of endogenous small RNAs, including microRNAs, endo-siRNAs and piRNAs, regulate gene expression states to impact diverse biological processes. Our lab focuses on understanding the nature and biological functions of small RNA pathways in animals. We have identified and characterized an evolutionary conserved small RNA pathway that operates in germ cells and that is critical both for germline stem cell maintenance and for gametogenesis. Working in Drosophila and mice, we discovered a new class of small RNAs, Piwi-interacting (pi)RNAs. Piwi/piRNA pathway plays an important role in genome integrity by repressing selfish repetitive elements. A characterization of piRNA sequences in combination with genetic studies revealed that the biogenesis and function of piRNAs differs from that of other classes of small RNAs. While canonical small RNAs, such as microRNAs, affect gene expression post-transcriptionally, our studies suggest that piRNAs most likely serve as guides for de novo DNA methylation in mouse male germ cells.
研究兴趣
论文共 128 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
引用0浏览0WOSNATURE引用
0
0
Daria Esyunina, Anastasiia Okhtienko,Anna Olina, Vladimir Panteleev,Maria Prostova,Alexei A Aravin,Andrey Kulbachinskiy
Nucleic Acids Research (2023)
引用0浏览0引用
0
0
Cellsno. 22 (2023): 2629-2629
JOURNAL OF BIOLOGICAL CHEMISTRYno. 3 (2023): S535-S535
引用0浏览0引用
0
0
MICROBIOLOGY SPECTRUMno. 3 (2023)
MOLECULAR CELLno. 21 (2023): 3835-+
Journal of Biological Chemistryno. 3 (2023): 103995-103995
bioRxiv : the preprint server for biology (2023)
CELL GENOMICSno. 7 (2023): 100329-100329
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn