Gingras Alexandre R

Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom.

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Differential Use of Rap1 Effectors for Integrin Activation in Platelets and Lymphocytes

Frederic Lagarrigue, Hao Sun,Alexandre R Gingras,Mark H Ginsberg

Blood, (2020): 27-28

Bibtex

Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling

Lai Wen,Alex Marki, Payel Roy,Sara McArdle, Hao Sun, Zhichao Fan,Alexandre R Gingras,Mark H Ginsberg,Klaus Ley

Blood, (2020)

WOSBibtex

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem

Alexandre R Gingras,Frederic Lagarrigue, Monica N Cuevas, Andrew J Valadez, Marcus Zorovich, Wilma McLaughlin,Miguel Alejandro Lopez-Ramirez, Nicolas Seban, Klaus Ley,William B Kiosses,Mark H Ginsberg

JOURNAL OF CELL BIOLOGY, no. 6 (2019): 1799.0-1809.0

WOSBibtex

Pharmacological inhibition of the heart of glass (HEG1)-Krev interaction trapped protein 1 (KRIT1) protein complex increases Krüppel-like Factors 4 and 2 (KLF4/2) expression in endothelial cells

Miguel Alejandro Lopez-Ramirez, Mark K. Haynes, Preston Hale, Killian Oukoloff, Matthew Bautista,Brendan Gongol,John Y. Shyy,Carlo Ballatore,Larry A. Sklar,Alexandre R. Gingras

Bibtex

Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling

Hao Sun, Zhichao Fan,Alexandre R Gingras, Miguel A Lopez-Ramirez,Mark H Ginsberg,Klaus Ley

Journal of leukocyte biology, (2019)

WOSBibtex

Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation

Frederic Lagarrigue,Alexandre R Gingras,David S Paul, Andrew J Valadez, Monica N Cuevas, Hao Sun,Miguel A Lopez-Ramirez,Benjamin T Goult,Sanford J Shattil,Wolfgang Bergmeier,Mark H Ginsberg

BLOOD ADVANCES, no. 18.0 (2018): 2358-2368

Cited by2WOSBibtex

A Rap1 binding site and lipid-dependent helix in talin F1 domain cooperate in integrin activation

Alexandre Gingras,Frederic Lagarrigue, Monica Cuevas, Marcus Zorovich, Andrew Valadez,Miguel Alejandro Lopez-Ramirez, Nicolas Seban, Wilma McLaughlin,Mark Ginsberg

bioRxiv, pp.504894-28, (2018)

Bibtex

Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development

Hao Sun,Frederic Lagarrigue,Alexandre R Gingras,Zhichao Fan,Klaus Ley,Mark H Ginsberg

JOURNAL OF CELL BIOLOGY, no. 4 (2018): 1453.0-1465

Cited by1WOSBibtex

Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins

Alexandre R Gingras,Wilma Puzon-McLaughlin,Andrey A Bobkov,Mark H Ginsberg

Structure (London, England : 1993), no. 12 (2016): 2152-2162

Cited by4WOSBibtex

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity

Bart-Jan de Kreuk,Alexandre R Gingras,James Dr Knight,Jian J Liu,Anne-Claude Gingras,Mark H Ginsberg

eLife, (2016)

Cited by12WOSBibtex

The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

Merry Gunawan,Nandini Venkatesan, Jia Tong Loh,Jong Fu Wong,Heidi Berger,Wen Hao Neo,Liang Yao Jackson Li, Myint Khun La Win,Yin Hoe Yau,Tiannan Guo,Peter Chi Ee See,Sayuri Yamazaki

Nature immunology, no. 5 (2015): 505-516

Cited by56WOSNATUREBibtex

Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome

Umakhanth Venkatraman Girija,Christopher M Furze,Alexandre R Gingras,Takayuki Yoshizaki,Katsuki Ohtani,Jamie E Marshall,A Katrine Wallis,Wilhelm J Schwaeble,Mohammed El-Mezgueldi,Daniel A Mitchell,Peter C E Moody,Nobutaka Wakamiya

BMC biology, (2015): 27-27

Cited by16WOSBibtex

Structural basis of junctional anchorage of the cerebral cavernous malformations complex

Jay Liu,Alexandre R. Gingras,Mark H. Ginsberg

ANGIOGENESIS, no. 1 (2013): 268-268

Bibtex

Integrins protect cardiomyocytes from ischemia/reperfusion injury

Hideshi Okada,N Chin Lai,Yoshitaka Kawaraguchi,Peter Liao,Jeffrey Copps,Yasuo Sugano,Sunaho Okada-Maeda,Indroneal Banerjee,Jan M Schilling,Alexandre R Gingras,Elizabeth K Asfaw,Jorge Suarez

JOURNAL OF CLINICAL INVESTIGATION, no. 10 (2013): 4294-4308

Cited by30WOSBibtex

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

Venkatraman Girija Umakhanth,Alexandre R. Gingras,Jamie E. Marshall,Panchal Roshni,Md. Arif Sheikh,Gál Péter,Wilhelm J. Schwaeble,Daniel A. Mitchell,Peter C. E. Moody,Wallis Russell

Proceedings of the National Academy of Sciences of the United States of America, no. 34 (2013): 13916-13920

Cited by47WOSBibtex

Reconstructing integrin activation in vitro

Alexandre R Gingras,Feng Ye,Mark H Ginsberg

Methods in molecular biology (Clifton, N.J.), (2013): 1-17

Cited by3WOSBibtex

The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail

Alexandre R Gingras,Wilma Puzon-McLaughlin,Mark H Ginsberg

The Journal of biological chemistry, no. 33 (2013): 23639-23649

Cited by18WOSBibtex

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation

Benjamin T Goult,Xiao-Ping Xu,Alexandre R Gingras,Mark Swift,Bipin Patel,Neil Bate,Petra M Kopp,Igor L Barsukov,David R Critchley,Niels Volkmann,Dorit Hanein

Journal of Structural Biology, no. 1 (2013): 21-32

Cited by61WOSBibtex

RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover

Benjamin T Goult,Thomas Zacharchenko,Neil Bate,Ricky Tsang,Fiona Hey,Alexandre R Gingras,Paul R Elliott,Gordon C K Roberts,Christoph Ballestrem,David R Critchley,Igor L Barsukov

The Journal of biological chemistry, no. 12 (2013): 8238-8249

Cited by83WOSBibtex

Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

Alexandre R Gingras,Jian J Liu,Mark H Ginsberg

JOURNAL OF CELL BIOLOGY, no. 1 (2012): 39-48

Cited by35WOSBibtex

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