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Associate Professor Alexandra Corbett completed a Bachelor of Science (Hons) at the University of Melbourne (1998) and PhD at the WEHI (2004). Following two post-doctoral positions at the Lions Eye Institute, UWA (supported by a WA & MG Saw Research Fellowship) and at the Bio21 Institute, she joined Professor Jim McCluskey’s Laboratory in the Department of Microbiology and Immunology in 2012, and now leads her own group. Her research has spanned areas of immunology including T cell biology, vaccine platform technologies, autoimmunity, viral immunology and immune evasion. Alex’s current focus is the biology and immune role of mucosal-associated invariant T (MAIT) cells.
Alex has made key discoveries in the field of mucosal-associated invariant T (MAIT) cells, an innate-like population of T cells restricted by the non-polymorphic MHC class I-related protein (MR1). With colleagues at the Universities of Melbourne, Monash and Queensland, she discovered that MAIT cells recognise a new class of antigen; vitamin metabolites made by bacteria and fungi (Nature 2012, 2014), and developed MR1-tetramer reagents to specifically identify MAIT cells in humans and mice. Her NHMRC- and ARC-funded research program seeks to understand what drives MAIT cell protective or pathogenic functions during infection and inflammatory disease, with the ultimate goal of targeting MAIT cells in vaccine or therapeutic strategies. Alex has authored over 60 research articles and reviews. She is a member of ASI and VIIN and has served on the Society for Mucosal Immunology Board of Councillors since 2019.
Alex has made key discoveries in the field of mucosal-associated invariant T (MAIT) cells, an innate-like population of T cells restricted by the non-polymorphic MHC class I-related protein (MR1). With colleagues at the Universities of Melbourne, Monash and Queensland, she discovered that MAIT cells recognise a new class of antigen; vitamin metabolites made by bacteria and fungi (Nature 2012, 2014), and developed MR1-tetramer reagents to specifically identify MAIT cells in humans and mice. Her NHMRC- and ARC-funded research program seeks to understand what drives MAIT cell protective or pathogenic functions during infection and inflammatory disease, with the ultimate goal of targeting MAIT cells in vaccine or therapeutic strategies. Alex has authored over 60 research articles and reviews. She is a member of ASI and VIIN and has served on the Society for Mucosal Immunology Board of Councillors since 2019.
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Lisa Ciacchi, Jeffrey Y.W. Mak, Jeremy P. Le,David P. Fairlie,James McCluskey,Alexandra J. Corbett,Jamie Rossjohn,Wael Awad
Journal of Biological Chemistrypp.107229-107229, (2024)
FRONTIERS IN IMMUNOLOGY (2023): 1121714-1121714
Adam G Nelson,Huimeng Wang, Phoebe M Dewar, Eleanor M Eddy, Songyi Li,Xin Yi Lim,Timothy Patton,Yuchen Zhou,Troi J Pediongco,Lucy J Meehan,Bronwyn S Meehan,Jeffrey Y W Mak,
Frontiers in immunology (2023): 1109759-1109759
Juming Yan, Stacey Allen,Elizabeth McDonald,Indrajit Das, Jeffrey Y.W. Mak,Ligong Liu,David P. Fairlie,Bronwyn S. Meehan,Zhenjun Chen,Alexandra J. Corbett,Antiopi Varelias,Mark J. Smyth,
crossref(2023)
Frontiers in immunology (2023): 1281881-1281881
Journal of Leukocyte Biology (2022)
Journal of immunology (Baltimore, Md. : 1950)no. 6 (2022): 1389-1395
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