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Cell polarity is a fundamental property of almost all cell types, and its loss or deregulation frequently leads to human diseases such as cancer. My lab is interested in the mechanisms that establish and maintain apico-basal polarity of epithelial cells. We are particularly interested in understanding how membrane compartmentalization controls cell polarity, on the cellular, molecular, and structural level.
One line of research focuses on the apical junctional complex (AJC), an intricate membrane compartment that is located at the boundary between the apical and the lateral membrane. The AJC plays many important roles in epithelial cells; it connects adjacent cells into a tight monolayer, it controls the passage of molecules across epithelial tissues, and it serves as a diffusion barrier that physically separates apical and baso-lateral membrane components. In addition, the AJC serves as a signaling and trafficking platform for epithelial morphogenesis and plasticity, and it is linked to the cortical cytoskeleton to regulate tissue mechanics. We are interested in the nanometer-scale organisation of the AJC and in identifying and functionally characterising novel regulators of this intriguing multi-functional membrane domain.
Another line of research tackles the regulation of the protein network that sets up cell polarity in the first place. Here we focus our efforts on the polarity proteins Par, Scribble and Crumbs, which are central to the establishment and maintenance of cell polarity. We are interested in the molecular and spatial organization of the polarity network, and in understanding how this network functions in time and space.
My lab combines cell biological, biochemical, and structural approaches with high-resolution imaging including light and electron microscopy and correlative imaging.
Cell polarity is a fundamental property of almost all cell types, and its loss or deregulation frequently leads to human diseases such as cancer. My lab is interested in the mechanisms that establish and maintain apico-basal polarity of epithelial cells. We are particularly interested in understanding how membrane compartmentalization controls cell polarity, on the cellular, molecular, and structural level.
One line of research focuses on the apical junctional complex (AJC), an intricate membrane compartment that is located at the boundary between the apical and the lateral membrane. The AJC plays many important roles in epithelial cells; it connects adjacent cells into a tight monolayer, it controls the passage of molecules across epithelial tissues, and it serves as a diffusion barrier that physically separates apical and baso-lateral membrane components. In addition, the AJC serves as a signaling and trafficking platform for epithelial morphogenesis and plasticity, and it is linked to the cortical cytoskeleton to regulate tissue mechanics. We are interested in the nanometer-scale organisation of the AJC and in identifying and functionally characterising novel regulators of this intriguing multi-functional membrane domain.
Another line of research tackles the regulation of the protein network that sets up cell polarity in the first place. Here we focus our efforts on the polarity proteins Par, Scribble and Crumbs, which are central to the establishment and maintenance of cell polarity. We are interested in the molecular and spatial organization of the polarity network, and in understanding how this network functions in time and space.
My lab combines cell biological, biochemical, and structural approaches with high-resolution imaging including light and electron microscopy and correlative imaging.
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bioRxiv (Cold Spring Harbor Laboratory)no. 5 (2024)
Anastasia Shebanova, Quentin Perrin,Sushanth Gudlur,Yue Sun,Zhi Wei Lim, Ruoxuan Sun,Sierin Lim,Alexander Ludwig,Ali Miserez
biorxiv(2022)
Barbara Hübner, Eric von Otter,Bilal Ahsan,Mei Ling Wee,Sara Henriksson,Alexander Ludwig,Sara Sandin
Nucleic Acids Research (2022)
Thuan Beng Saw,Xumei Gao, Muchun Li, Jianan He,Anh Phuong Le, Supatra Marsh,Keng-hui Lin,Alexander Ludwig,Jacques Prost,Chwee Teck Lim
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