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Aims and areas of interest
Our specific aims are to
Phenotypically characterize and visualize primary definitive HSCs in the early embryo
Identify embryonic ancestor cells which develop into HSCs
Identify routes and mechanisms of hematopoietic stem cell migration
Identify and characterize transcription and growth factors as well as extracellular signaling and matrix molecules responsible for the process of initiation, expansion and migration of HSCs.
Based on the knowledge of mechanisms underlying development of HSCs in vivo, develop new protocols for generation of definitive long-term repopulating HSCs from ES cells (so far attempts to achieve this by different laboratories without employing genetic intervention have been unsuccessful).
Our specific aims are to
Phenotypically characterize and visualize primary definitive HSCs in the early embryo
Identify embryonic ancestor cells which develop into HSCs
Identify routes and mechanisms of hematopoietic stem cell migration
Identify and characterize transcription and growth factors as well as extracellular signaling and matrix molecules responsible for the process of initiation, expansion and migration of HSCs.
Based on the knowledge of mechanisms underlying development of HSCs in vivo, develop new protocols for generation of definitive long-term repopulating HSCs from ES cells (so far attempts to achieve this by different laboratories without employing genetic intervention have been unsuccessful).
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EXPERIMENTAL HEMATOLOGY (2021): S20-S20
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Marleen Büchler-Schäff,Paul Kaschutnig,Roshana Thambyrajah,Wiebke Nadler, Sabrina Hanke,Stella Pfaffenholz, Milena Block, Julius Gräsel, Jakob Kremer, Irem Bayindir-Buchhalter, Wenjun Chang,David Hills,
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